α-Synuclein Degrader 2b

Tocris Bioscience | Catalog # 8040

α-synuclein Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

α-synuclein Degrader (PROTAC®)
View all Active Degraders »

Product Description

α-Synuclein Degrader 2b is a selective α-synuclein Degrader (PROTAC®) (DC50 = 7.5 μM; Dmax = 89%). Comprises the probe molecule sery308, joined by a linker to a pomalidomide E3 ligase ligand. Activates both proteasomal and lysosomal degradation pathways. Protects SH-SY5Y cells from α-synuclein-induced cytotoxicity. Cell permeable.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for α-Synuclein Degrader 2b

Molecular Weight

767.80

Formula

C39H41N7O10

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide

CAS Number

2781922-42-5

InChI Key

IYFKRANQUJUTKF-UHFFFAOYSA-N

SMILES

O=C(CNC1=CC=CC(C2=NNC(C3=CC4=C(OCO4)C=C3)=C2)=C1)NCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 76.78 100

Preparing Stock Solutions for α-Synuclein Degrader 2b

The following data is based on the product molecular weight 767.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.30 mL 6.51 mL 13.02 mL
5 mM 0.26 mL 1.30 mL 2.60 mL
10 mM 0.13 mL 0.65 mL 1.30 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for α-Synuclein Degrader 2b

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for α-Synuclein Degrader 2b

For research use only

Citations for α-Synuclein Degrader 2b

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