AM 404

Tocris Bioscience | Catalog # 1116

Anandamide transport inhibitor
Tocris Bioscience

Key Product Details

Description

Anandamide transport inhibitor
View all Cannabinoid Transporter Inhibitors »

Product Description

AM 404 is a competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Also FABP inhibitor. Active in vivo.

Product Specifications for AM 404

Molecular Weight

395.58

Formula

C26H37NO2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

CAS Number

183718-77-6

PubChem ID

6604822

InChI Key

IJBZOOZRAXHERC-DOFZRALJSA-N

SMILES

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.78 50
Ethanol 19.78 50

Preparing Stock Solutions for AM 404

The following data is based on the product molecular weight 395.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.06 mL 25.28 mL 50.56 mL
2.5 mM 1.01 mL 5.06 mL 10.11 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
25 mM 0.10 mL 0.51 mL 1.01 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 73 publications citing the usage of this product.

Product Documents for AM 404

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AM 404

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for AM 404 (1)

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  • AM404 administered in vivo works to reduce operant behavior
    Name: Carol Gianessi
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 05/23/2019
    use DMSO and Tween 80 to get AM404 into solution
    administered to mice prior to operant behavior
    AM 404 1116

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