AM 6545

Tocris Bioscience | Catalog # 5443

High affinity and selective CB1 antagonist
Tocris Bioscience

Key Product Details

Description

High affinity and selective CB1 antagonist
View all Cannabinoid R1/CB1 Antagonists »

Product Description

AM 6545 is a high affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits >100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.

Product Specifications for AM 6545

Molecular Weight

556.46

Formula

C26H23Cl2N5O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide

CAS Number

1245626-05-4

PubChem ID

46912919

InChI Key

XBHQLFVDGLPBCK-UHFFFAOYSA-N

SMILES

O=C(NN3CCS(CC3)(=O)=O)C1=NN(C2=CC=C(Cl)C=C2Cl)C(C4=CC=C(C#CCCC#N)C=C4)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.13 20

Preparing Stock Solutions for AM 6545

The following data is based on the product molecular weight 556.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.99 mL 44.93 mL 89.85 mL
1 mM 1.80 mL 8.99 mL 17.97 mL
2 mM 0.90 mL 4.49 mL 8.99 mL
10 mM 0.18 mL 0.90 mL 1.80 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for AM 6545

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AM 6545

For research use only

Related Research Areas

Bioactive Lipids and Receptors

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