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AM 6545

Catalog #: 5443 Datasheet / COA / SDS
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5443/10
5443/50
AM 6545 | CAS No. 1245626-05-4 | Cannabinoid R1/CB1 Antagonists
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Description: High affinity and selective CB1 antagonist

Chemical Name: 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide

Purity: ≥98%

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Biological Activity

AM 6545 is a high affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits >100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.

Technical Data

M.Wt:
556.46
Formula:
C26H23Cl2N5O3S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1245626-05-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Research

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Complete Your Experiment

Rat Cannabinoid R1/CB1/CNR1 (NP_036916) VersaClone cDNA
Cat # RDC0757
Human Cannabinoid R1/CB1/CNR1 (NP_057167) VersaClone cDNA
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Mouse Cannabinoid R1/CB1/CNR1 (NP_031752) VersaClone cDNA
Cat # RDC0222

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FAQs

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VersaClone cDNA Plasmids

Human Cannabinoid R1/CB1/CNR1 (NP_057167) VersaClone cDNA

RDC0109

Mouse Cannabinoid R1/CB1/CNR1 (NP_031752) VersaClone cDNA

RDC0222

Rat Cannabinoid R1/CB1/CNR1 (NP_036916) VersaClone cDNA

RDC0757

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