AM 6545

Catalog # Availability Size / Price Qty
5443/10
5443/50
Cat.No. 5443 - AM 6545 | C26H23Cl2N5O3S | CAS No. 1245626-05-4
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Description: High affinity and selective CB1 antagonist

Chemical Name: 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide

Purity: ≥98%

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Biological Activity

High affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits >100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.

Technical Data

M.Wt:
556.46
Formula:
C26H23Cl2N5O3S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1245626-05-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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