AMD 3465 hexahydrobromide
Chemical Name: N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
Biological ActivityAMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor.
Rosenkilde et al.
Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4.
Bodart et al.
Citations for AMD 3465 hexahydrobromide
The citations listed below are publications that use Tocris products. Selected citations for AMD 3465 hexahydrobromide include:
2 Citations: Showing 1 - 2
Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain.
Authors: Luo Et al.
Mol Pain 2016;12
Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
Authors: Lourenco Et al.
J Immunol 2015;194:3463
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Receptor antagonists (SB225002: for CXCR2, AMD3465: for CXCR4, RS504393: for CCR2 and Maraviroc: for CCR5) at 10 μM