AMD 3465 hexahydrobromide

Tocris Bioscience | Catalog # 4179

Potent and selective CXCR4 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective CXCR4 antagonist
View all Chemokine Receptor Antagonists »

Product Description

AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.

Product Specifications for AMD 3465 hexahydrobromide

Molecular Weight

896.07

Formula

C24H38N6.6HBr

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

CAS Number

185991-07-5

PubChem ID

9897616

InChI Key

ARHBIBDGWDRBJH-UHFFFAOYSA-N

SMILES

C1(CN3CCCNCCNCCCNCC3)=CC=C(CNCC2=NC=CC=C2)C=C1.Br.Br.Br.Br.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.8 50
DMSO 22.4 25

Preparing Stock Solutions for AMD 3465 hexahydrobromide

The following data is based on the product molecular weight 896.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.23 mL 11.16 mL 22.32 mL
2.5 mM 0.45 mL 2.23 mL 4.46 mL
5 mM 0.22 mL 1.12 mL 2.23 mL
25 mM 0.04 mL 0.22 mL 0.45 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for AMD 3465 hexahydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMD 3465 hexahydrobromide

For research use only

Citations for AMD 3465 hexahydrobromide

Customer Reviews for AMD 3465 hexahydrobromide (1)

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  • Used for Migration assays
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: A549 or MDAMB231
    Verified Customer | Posted 07/01/2020
    We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
    Receptor antagonists (SB225002: for CXCR2, AMD3465: for CXCR4, RS504393: for CCR2 and Maraviroc: for CCR5) at 10 μM
    AMD 3465 hexahydrobromide 4179

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