Catalog Number: 4179
Chemical Name: N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
Biological Activity
Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.
Technical Data
  • M.Wt:
    896.07
  • Formula:
    C24H38N6.6HBr
  • Solubility:
    Soluble to 50 mM in water and to 25 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    185991-07-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor.
    Rosenkilde et al.
    J.Biol.Chem., 2007;282:27354
  2. Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4.
    Bodart et al.
    Biochem.Pharmacol., 2009;78:993
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AMD 3465 hexahydrobromide include:

1 Citations: Showing 1 - 1

  1. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
    Authors: Lourenco Et al.
    J Immunol 2015;194:3463

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