11 results for "Chemokine CXC Receptor Antagonists" in Products
Chemokine CXC Receptor Antagonists
Chemokine CXC receptors (CXCRs) predominantly recognize CXC chemokines. CXC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being separated by a single amino acid. There are six chemokine CXC receptors, CXCR1 to 6, with each one having a distinct chemokine and leukocyte specificity.
CXCR1 and 2 are expressed on neutrophils and monocytes/macrophages, and are involved in acute inflammation and innate immunity. CXCR3 is expressed on circulating T ...
Highly selective CXCR4 antagonist
| Alternate Names: | JM 3100,Plerixafor |
| Chemical Name: | 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride |
CXCR3 antagonist; inhibits cell migration and metastasis
| Chemical Name: | N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide |
| Purity: | ≥98% |
Potent and selective CXCR2 antagonist
| Chemical Name: | N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea |
| Purity: | ≥98% |
Potent CXCR2 antagonist
| Chemical Name: | N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea |
| Purity: | ≥98% |
Potent and selective CXCR4 antagonist
| Chemical Name: | N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide |
| Purity: | ≥97% |
Potent and selective CXCR3 antagonist
| Chemical Name: | N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide |
| Purity: | ≥98% |
Potent CXCR4 antagonist
| Chemical Name: | N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride |
| Purity: | ≥98% |
CXCR4 antagonist; antitumor
| Purity: | ≥95% |
Potent CXCR2 antagonist
| Chemical Name: | 6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide |
| Purity: | ≥98% |
Potent CXCR2 antagonist
| Chemical Name: | 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one |
| Purity: | ≥98% |
Potent and selective hCXCR6 antagonist
| Chemical Name: | N-[(1R,3S,5S)-9-(2-((2-Chlorophenyl)amino)-2-exoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide |
| Purity: | ≥98% |
