(±)-AMG 487

  ( 1 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4487
Chemical Name:N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.

This product is racemic.

Technical Data
  • M.Wt:
    603.59
  • Formula:
    C32H28F3N5O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    947536-03-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • This compound is racemic
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (±)-AMG 487 include:

1 Citations: Showing 1 - 1

  1. Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration.
    Authors: Gordón-Alonso Et al.
    Nat Commun  2017;8:793

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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human CXCR3B (NP_001136269) VersaClone cDNA

RDC0030
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Rat CXCR3 (NP_445867) VersaClone cDNA

RDC0243
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Human CXCR3 (NP_001495) VersaClone cDNA

RDC0029
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Mouse CXCR3 (AAC40163) VersaClone cDNA

RDC0031
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Average Rating: 4 (Based on 1 review)

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  Mouse Udai Singh 01/04/2018
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Species Mouse

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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