Catalog Number: 4487
Chemical Name: N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide
Biological Activity
Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.

This product is racemic.

Technical Data
  • M.Wt:
    603.59
  • Formula:
    C32H28F3N5O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    947536-03-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • This compound is racemic
Background References
  1. Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.
    Johnson et al.
    Bioorg.Med.Chem.Lett., 2007;17:3339
  2. Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer.
    Walser et al.
    Cancer Res., 2006;66:7701
  3. Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism.
    Cambien et al.
    Br.J.Cancer, 2009;100:1755

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