(±)-AMG 487

Catalog # Availability Size / Price Qty
4487/10
4487/50
Cat.No. 4487 - (�)-AMG 487 | C32H28F3N5O4 | CAS No. 947536-03-0
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Description: CXCR3 antagonist; inhibits cell migration and metastasis

Chemical Name: N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.

This product is racemic.

Technical Data

M.Wt:
603.59
Formula:
C32H28F3N5O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
947536-03-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Other Product-Specific Information:
  • This compound is racemic

Product Datasheets

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Citation for (±)-AMG 487

The citations listed below are publications that use Tocris products. Selected citations for (±)-AMG 487 include:

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AMG 487 reduces the symptoms and inflammation in interstitial cystitis.
By Udai Singh on 01/04/2018
Species: Mouse

I used this product to reduce the activated CXCR3+ T cells in mouse with chronic interstitial cystitis.


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