Antagonist of CXCR3; inhibits binding of 125
I-IP-10 and 125
I-ITAC to CXCR3 (IC50
values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro
values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.
Johnson et al.
Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer.
Walser et al.
Cancer Res., 2006;66:7701
Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism.
Cambien et al.