AMG 9810

Tocris Bioscience | Catalog # 2316

Potent and selective TRPV1 competitive antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective TRPV1 competitive antagonist
View all TRPV Antagonists »

Product Description

AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.

Product Specifications for AMG 9810

Molecular Weight

337.42

Formula

C21H23NO3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide

CAS Number

545395-94-6

PubChem ID

680502

InChI Key

GZTFUVZVLYUPRG-IZZDOVSWSA-N

SMILES

CC(C)(C)C1=CC=C(C=C1)\C=C\C(=O)NC1=CC=C2OCCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.87 50
Ethanol 33.74 100

Preparing Stock Solutions for AMG 9810

The following data is based on the product molecular weight 337.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.30 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.30 mL 0.59 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 91 publications citing the usage of this product.

Product Documents for AMG 9810

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMG 9810

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for AMG 9810 (1)

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  • CaMKII inhibitors
    Name: Padmamalini Baskaran
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK 293 cells
    Verified Customer | Posted 01/01/2020
    We used KN62 for calcium imaging experiments and western blotting work. The data were published in Br. J Pharmacol. 2017
    AMG 9810 2316

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