AMG 9810

  ( 13 citations )    
Product Datasheet
Catalog Number:2316
Chemical Name:(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
Potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.
Technical Data
  • M.Wt:
    337.42
  • Formula:
    C21H23NO3
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    545395-94-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AMG 9810 include:

13 Citations: Showing 1 - 10
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  1. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
    Authors: David-Pereira
    Neuroscience  2017;349:341
  2. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
    Authors: Martin Et al.
    Oncotarget  2015;9:457
  3. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4.
    Authors: Li Et al.
    J Neurosci  2015;35:13487
  4. Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complet Freund's Adjuvant-induced mice: roles of dynorpin/κ-opioid system and transient receptor potential vanilloid type-1 ion channel.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A  2015;13:284
  5. Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels.
    Authors: Montrucchio Et al.
    PLoS One  2013;8:e67730
  6. P2X? and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons.
    Authors: Saloman Et al.
    Neuroscience  2013;232:226
  7. 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
    Authors: Sisignano Et al.
    J Neurosci  2012;32:6364
  8. Endocannabinoid System and TRPV1 Receptors in the Dorsal Hippocampus of the Rats Modulate Anxiety-like Behaviors.
    Authors: Hakimizadeh Et al.
    Iran J Basic Med Sci  2012;15:795
  9. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.
    Authors: Gregus Et al.
    Proc Natl Acad Sci U S A  2012;109:6721
  10. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.
    Authors: Park Et al.
    Front Cell Neurosci  2011;31:18433
  11. Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache.
    Authors: Yan Et al.
    Pain  2011;152:106
  12. Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia.
    Authors: Patwardhan Et al.
    J Neurosci  2009;106:18820
  13. Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia.
    Authors: Pitcher Et al.
    J Transl Med  2007;3:17
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