Amlexanox

Catalog # Availability Size / Price Qty
4857/10
4857/50
Cat.No. 4857 - Amlexanox | C16H14N2O4 | CAS No. 68302-57-8
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Description: Selective inhibitor of TBK

Chemical Name: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC50 values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.

Technical Data

M.Wt:
298.29
Formula:
C16H14N2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
68302-57-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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