Catalog Number: 4857
Chemical Name: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Biological Activity
Selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC50 values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.
Technical Data
  • M.Wt:
    298.29
  • Formula:
    C16H14N2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    68302-57-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice.
    Reilly et al.
    Nat.Med., 2012;19:313
  2. Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox.
    Okada et al.
    Biochem.J., 2003;374:433
  3. Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase.
    Makino et al.
    Int.Arch.Allergy Appl.Immunol., 1987;82:66
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amlexanox include:

1 Citations: Showing 1 - 1

  1. Full UPF3B function is critical for neuronal differentiation of neural stem cells.
    Authors: Alrahbeni Et al.
    Br J Pharmacol 2015;8:33

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