Selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε
values are ~1-2 μ
M). Displays no effect on IKKα
at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro
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An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice.
Reilly et al.
Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox.
Okada et al.
Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase.
Makino et al.
Int.Arch.Allergy Appl.Immunol., 1987;82:66
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