Amlexanox

  ( 1 citations )    
Product Datasheet
Catalog Number:4857
Chemical Name:2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Product Details
Citations (1)
Reviews
Biological Activity
Selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC50 values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.
Technical Data
  • M.Wt:
    298.29
  • Formula:
    C16H14N2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    68302-57-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amlexanox include:

1 Citations: Showing 1 - 1

  1. Full UPF3B function is critical for neuronal differentiation of neural stem cells.
    Authors: Alrahbeni Et al.
    Br J Pharmacol  2015;8:33

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