Chemical Name: 2-Amino-7-(1-methylethyl)-5-oxo-5H-benzopyrano[2,3-b]pyridine-3-carboxylic acid
Biological ActivitySelective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC50 values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amle.
Okada et al.
Mechanism of action of an antiallergic agent, amle. (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase.
Makino et al.
Int.Arch.Allergy Appl.Immunol., 1987;82:66
An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice.
Reilly et al.
Citation for Amlexanox
The citations listed below are publications that use Tocris products. Selected citations for Amlexanox include:
1 Citation: Showing 1 - 1
Full UPF3B function is critical for neuronal differentiation of neural stem cells.
Authors: Alrahbeni Et al.
Br J Pharmacol 2015;8:33
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