Chemical Name: 2-Amino-7-(1-methylethyl)-5-oxo-5H-benzopyrano[2,3-b]pyridine-3-carboxylic acid
Biological ActivitySelective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC50 values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice.
Reilly et al.
Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amle.
Okada et al.
Mechanism of action of an antiallergic agent, amle. (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase.
Makino et al.
Int.Arch.Allergy Appl.Immunol., 1987;82:66
Citation for Amlexanox
The citations listed below are publications that use Tocris products. Selected citations for Amlexanox include:
1 Citation: Showing 1 - 1
Full UPF3B function is critical for neuronal differentiation of neural stem cells.
Authors: Alrahbeni Et al.
Br J Pharmacol 2015;8:33
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