Chemical Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Biological ActivityForms nonselective monovalent ion channels within lipid bilayers. Binds ergosterol in the cell membrane. Antifungal.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia.
Muruglia et al.
Amphotericin B: 30 years of clinical experience.
Gallis et al.
Current concepts in antifungal pharmacology.
Mayo Clin.Proc., 2011;86:805
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