Amphotericin B

Tocris Bioscience | Catalog # 6930

Forms monovalent ion channels in lipid bilyers; antifungal
Tocris Bioscience

Key Product Details

Description

Forms monovalent ion channels in lipid bilyers; antifungal
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Product Description

Amphotericin B forms nonselective monovalent ion channels within lipid bilayers. Amphotericin B binds ergosterol in the cell membrane. Antifungal and antiprotozoal. Amphotericin B can be used in a small molecule cocktail to generate 3D culture of lung alveolar cells (see below protocol).

For more information about how Amphotericin B may be used, see our protocol: 3D Culture of Lung Alveolar Cells

Product Specifications for Amphotericin B

Molecular Weight

924.09

Formula

C47H73NO17

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

CAS Number

1397-89-3

PubChem ID

5280965

InChI Key

APKFDSVGJQXUKY-INPOYWNPSA-N

SMILES

[H][C@]12C[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.48 20

Preparing Stock Solutions for Amphotericin B

The following data is based on the product molecular weight 924.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 5.41 mL 27.05 mL 54.11 mL
1 mM 1.08 mL 5.41 mL 10.82 mL
2 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.11 mL 0.54 mL 1.08 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for Amphotericin B

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Amphotericin B

For research use only

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