Chemical Name: N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
Biological ActivityAMTB hydrochloride is a TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome.
Lashinger et al.
Am.J.Physiol.Renal Physiol., 2008;295:F803
Citations for AMTB hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AMTB hydrochloride include:
6 Citations: Showing 1 - 6
Structural insights into TRPM8 inhibition and desensitization.
Authors: Diver Et al.
Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium.
Authors: Melikov Et al.
Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.
Authors: Morgan Et al.
Biosci Rep 2015;35
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Authors: Sałat and Filipek
Biochem J 2015;16:167
Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8.
Authors: Liu Et al.
J Appl Physiol (1985) 2015;118:635
Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
Authors: Mueller-Tribbensee Et al.
PLoS One 2015;10:e0128242
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