Catalog Number: 3989
Chemical Name: N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
Biological Activity
TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
Technical Data
  • M.Wt:
    430.99
  • Formula:
    C23H26N2O2S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    926023-82-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome.
    Lashinger et al.
    Am.J.Physiol.Renal Physiol., 2008;295:F803
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AMTB hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium.
    Authors: Melikov Et al.
    Autophagy 2015;471:221
  2. Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.
    Authors: Morgan Et al.
    Biosci Rep 2015;35
  3. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
    Authors: Sałat and Filipek
    Biochem J 2015;16:167
  4. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
    Authors: Mueller-Tribbensee Et al.
    PLoS One 2015;10:e0128242

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