Anpirtoline hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:0703
Chemical Name:6-Chloro-2-[piperidinyl-4-thio]pyridine hydrochloride
Product Details
Citations (2)
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Reviews
Biological Activity
Highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively). Decreases central serotonin synthesis and attenuates aggressive behavior in vivo. Also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant.
Technical Data
  • M.Wt:
    265.2
  • Formula:
    C10H13ClN2S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    99201-87-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Anpirtoline hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Serotonin regulates prostate growth through androgen receptor modulation.
    Authors: Carvalho-Dias
    Sci Rep  2017;7(1):15428
  2. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One  2009;4:e6453

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