Anpirtoline hydrochloride

Key Product Details

Product Description

Anpirtoline hydrochloride is a highly potent 5-HT_1B receptor agonist (K_i values are 28, 150 and 1490 nM at 5-HT_1B, 5-HT_1A and 5-HT₂ receptors respectively). Decreases central serotonin synthesis and attenuates aggressive behavior in vivo. Also acts as an antagonist at 5-HT₃ receptors (K_i = 29.5 nM) and is brain penetrant.

Product Specifications for Anpirtoline hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Anpirtoline hydrochloride

The following data is based on the product molecular weight 265.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.77 mL	18.85 mL	37.71 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
10 mM	0.38 mL	1.89 mL	3.77 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Watanabe Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nucl.Med.Biol. 2006 PMID: 16631081
• Göthert 5HT₃ receptor antagonism by anpirtoline, a mixed 5HT₁ receptor agonist/5HT₃ receptor antagonist. Br.J.Pharmacol. 1995 PMID: 7881726
• Swedberg D-16949 (anpirtoline): a novel serotonergic (5-HT_1B) psychotherapeutic agent assessed by its discriminative effect in the rat. J.Pharmacol.Exp.Ther. 1992 PMID: 1335050
• Almeida and Miczek Aggression escalates by social instigation or by discontinuation of reinforcement ("frustration") in mice: inhibition by anpirtoline: a 5-HT_1B receptor agonist. Neuropsychopharmacology 2002 PMID: 12093591

Product Documents for Anpirtoline hydrochloride