Highly potent 5-HT1B
receptor agonist (Ki
values are 28, 150 and 1490 nM at 5-HT1B
receptors respectively). Decreases central serotonin synthesis and attenuates aggressive behavior in vivo
. Also acts as an antagonist at 5-HT3
= 29.5 nM) and is brain penetrant.
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All Tocris products are intended for laboratory research use only.
Aggression escalates by social instigation or by discontinuation of reinforcement ("frustration") in mice: inhibition by anpirtoline: a 5-HT1B receptor agonist.
Almeida and Miczek
5HT3 receptor antagonism by anpirtoline, a mixed 5HT1 receptor agonist/5HT3 receptor antagonist.
G?thert et al.
Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study.
Watanabe et al.
D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effect in the rat.
Swedberg et al.
The citations listed below are publications that use Tocris products. Selected citations for Anpirtoline hydrochloride include:
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