AP C5

Tocris Bioscience | Catalog # 6626

Potent and selective PKG2 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective PKG2 inhibitor
View all Protein Kinase G Inhibitors »

Product Description

AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Product Specifications for AP C5

Molecular Weight

275.31

Formula

C16H13N5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine

CAS Number

2234272-10-5

PubChem ID

137919866

InChI Key

QKHQFSQJQKGFAA-UHFFFAOYSA-N

SMILES

C#CCNC1=NC(C2=CC=C(N3C=CN=C3)C=C2)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 27.53 100
DMSO 27.53 100

Preparing Stock Solutions for AP C5

The following data is based on the product molecular weight 275.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AP C5

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AP C5

For research use only

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  • Development of a model system to form purified alternative pathway (AP) C5 convertases
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/24/2019
    We developed a model system to form purified alternative pathway (AP) C5 convertases on C3b-coated beads and quantify C5 conversion via functional analysis of released C5a.
    AP C5 6626

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