Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME
(Cat.No. 4506)) in vitro
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Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Sackton KL, Dimova N, Zeng X et al.
Targeting Cdc20 as a novel cancer therapeutic strategy.
Wang et al.