Apcin

Catalog # Availability Size / Price Qty
5747/10
5747/50
Cat.No. 5747 - Apcin | C13H14Cl3N7O4 | CAS No. 300815-04-7
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Description: Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.

Technical Data

M.Wt:
438.65
Formula:
C13H14Cl3N7O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
300815-04-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
    Sackton KL, Dimova N, Zeng X et al.
    Nature.
  2. Targeting Cdc20 as a novel cancer therapeutic strategy.
    Wang et al.
    Pharmacol.Ther., 2015;151:141

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