Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
Biological ActivityApcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Sackton KL, Dimova N, Zeng X et al.
Targeting Cdc20 as a novel cancer therapeutic strategy.
Wang et al.
Citations for Apcin
The citations listed below are publications that use Tocris products. Selected citations for Apcin include:
5 Citations: Showing 1 - 5
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation.
Authors: Venturina Et al.
Life Sci Alliance 2023;6
Kinetochore deterioration concommitant with centromere weakening during aging in mouse oocyte meiosis-I.
Authors: Lin Et al.
FASEB J 2023;37:e22922
Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit.
Authors: Shabaz Et al.
Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk.
Authors: Afonso Et al.
Tetraploidy causes chromosomal instability in acentriolar mouse embryos.
Authors: Greg Et al.
Nat Commun 2019;10:4834
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