Biological ActivityEndogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Apelin peptides block the entry of human immunodeficiency virus (HIV).
Zou et al.
FEBS Lett., 2000;473:15
Molecular properties of apelin: tissue distribution and receptor binding.
Kawamata et al.
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Tatemoto et al.
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