Biological ActivityApelin-36 (rat, mouse) is an endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Apelin peptides block the entry of human immunodeficiency virus (HIV).
Zou et al.
FEBS Lett., 2000;473:15
Molecular properties of apelin: tissue distribution and receptor binding.
Kawamata et al.
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Tatemoto et al.
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