APH1B encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. APH1B represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
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Key Product Details
Species Reactivity
Human, Mouse, Rat, C. elegans
Applications
Western Blot, ELISA
Label
Unconjugated
Antibody Source
Polyclonal Rabbit
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Product Specifications
Immunogen
Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein.
Clonality
Polyclonal
Host
Rabbit
Scientific Data Images for APH1B Antibody
APH1B Antibody [NBP3-12452] - 1:500 antibody dilution in Diluobuffer. Apparent MW is 34 KDa.
Applications for APH1B Antibody
Application
Recommended Usage
ELISA
1:10000
Western Blot
1:500
Formulation, Preparation, and Storage
Purification
Affinity purified
Formulation
Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).
Preservative
0.02% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
Background: APH1B
Long Name
Anterior Pharynx Defective 1 Homolog B
Alternate Names
PSFL
Gene Symbol
APH1B
Additional APH1B Products
Product Documents for APH1B Antibody
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for APH1B Antibody
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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Protocols
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