Catalog Number: 4663
Chemical Name: 4'-Hydroxy-3'-methoxyacetophenone
Biological Activity
NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.
Technical Data
  • M.Wt:
    166.17
  • Formula:
    C9H10O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    498-02-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol.
    Stolk et al.
    Am.J.Respir.Cell Mol.Biol., 1994;11:95
  2. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation.
    Impellizzeri et al.
    Biochem.Pharmacol., 2011;81:636
  3. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant.
    Heum?ller et al.
    Hypertension, 2008;51:211
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Apocynin include:

2 Citations: Showing 1 - 2
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  1. The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.
    Authors: Walsh Et al.
    Redox Biol 2014;2:178
  2. Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats.
    Authors: Hassler Et al.
    Int J Mol Med 2014;131:413

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