Chemical Name: 4'-Hydroxy-3'-methoxyacetophenone
Biological ActivityNADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol.
Stolk et al.
Am.J.Respir.Cell Mol.Biol., 1994;11:95
Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation.
Impellizzeri et al.
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant.
Heum?ller et al.
Citations for Apocynin
The citations listed below are publications that use Tocris products. Selected citations for Apocynin include:
3 Citations: Showing 1 - 3
Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment.
Authors: Michaeli Et al.
The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.
Authors: Walsh Et al.
Redox Biol 2014;2:178
Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats.
Authors: Hassler Et al.
Int J Mol Med 2014;131:413
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Apocynin is a NADPH oxidase inhibitor. It blocks NADPH oxidase in rat brain slice at 1mM.