Catalog # Availability Size / Price Qty
Apocynin | CAS No. 498-02-2 | NADPH Oxidase Inhibitors
1 Image
Description: NADPH-oxidase inhibitor

Chemical Name: 4'-Hydroxy-3'-methoxyacetophenone

Purity: ≥99%

Product Details
Citations (11)

Biological Activity

Apocynin is an NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Apocynin is bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Specific pathways mediating inflammasome activation by Candida parapsilosis
    A Tóth, E Zajta, K Csonka, C Vágvölgyi, MG Netea, A Gácser
    Sci Rep, 2017;7(0):43129.
  2. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol.
    Stolk et al.
    Am.J.Respir.Cell Mol.Biol., 1994;11:95
  3. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation.
    Impellizzeri et al.
    Biochem.Pharmacol., 2011;81:636
  4. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant.
    Heum?ller et al.
    Hypertension, 2008;51:211
  5. The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress
    NC Ferreira J, M Dos Santos, N Francis, P Ramirez, P Martorell, F González-L, B Figadère, R Chehin, E Del Bel, R Raisman-Vo, PP Michel
    Cells, 2021;10(8):.

Product Datasheets

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Citations for Apocynin

The citations listed below are publications that use Tocris products. Selected citations for Apocynin include:

11 Citations: Showing 1 - 10

  1. Interleukin-1 receptor antagonism leads to improved anaemia in a murine model of sickle cell disease and is associated with reduced ex vivo platelet-mediated erythrocyte sickling.
    Authors: Chiao Et al.
    Br J Haematol  2022;196:1040-1051
  2. Ginsenoside Rh1 Inhibits Angiotensin II-Induced Vascular Smooth Muscle Cell Migration and Proliferation through Suppression of the ROS-Mediated ERK1/2/p90RSK/KLF4 Signaling Pathway.
    Authors: Kyung-Sun Et al.
    Antioxidants (Basel)  2022;11
  3. Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells.
    Authors: Timothy S Et al.
    J Immunol  2021;207:1275-1287
  4. Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling.
    Authors: Kyung-Sun Et al.
    Cancers (Basel)  2021;13
  5. Controlled Feeding of an 8-d, High-Dairy Cheese Diet Prevents Sodium-Induced Endothelial Dysfunction in the Cutaneous Microcirculation of Healthy, Older Adults through Reductions in Superoxide.
    Authors: Richard S Et al.
    J Nutr  2020;150:55-63
  6. Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation.
    Authors: Minsoo Et al.
    Cell Rep  2019;28:2923-2938.e8
  7. NADPH Oxidase Mediates Membrane Androgen Receptor-Induced Neurodegeneration.
    Authors: Rebecca L Et al.
    Endocrinology  2019;160:947-963
  8. Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine.
    Authors: Rita Et al.
    Glia  2018;66:2353-2365
  9. Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment.
    Authors: Michaeli Et al.
    Oncoimmunology  2017;6:e1356965
  10. The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.
    Authors: Walsh Et al.
    Redox Biol  2014;2:178


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