Apolipoprotein A5 Antibody (4H8H8E2) - BSA Free

Novus Biologicals | Catalog # NB400-138

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 4H8H8E2

Format

BSA Free
View all Apolipoprotein A5 Primary Antibodies »

Product Specifications

Immunogen

Ni-NTA purified full-length recombinant human Apolipoprotein A5 expressed in E. Coli strain BL21 (DE3). [UniProt# Q6Q788]

Reactivity Notes

Immunogen sequence has 83% identity to Bovine, 79% identity to rat and 78% identity to mouse.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for Apolipoprotein A5 Antibody (4H8H8E2) - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000
Application Notes
This Apolipoprotein A5 antibody is useful for ELISA.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Ascites

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Apolipoprotein A5

Apolipoprotein A-V (APOA5) belongs to apolipoprotein A1/A4/E family and is a component of several lipoprotein fractions, including VLDL, HDL and chylomicrons. Expressed at high levels in plasma and liver, APOA5 exists as a secreted protein and interacts with GPIHBP1. APOA5 is an important determinant of plasma triglyceride levels by both behaving as a potent stimulator of apo-CII lipoprotein lipase/LPL TG hydrolysis and an inhibitor of hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). APOA5 activates lecithin: cholesterol acyltransferase (LCAT) but does not enhance efflux of cholesterol from macrophages. Transgenic mice overexpressing human APOA5 gene exhibit one-third lower plasma TG levels than wild type, whereas APOA5 knockout mice possess four times as much plasma TG levels, with no effect on plasma cholesterol levels. Clinically, defects in APOA5 are a cause of susceptibility to familial hypertriglyceridemia (FHTR) and hyperlipoproteinemia type 5 (HLPP5).

Alternate Names

APOAV, apo-AV, APOA-V, Apolipoprotein A5, apolipoprotein A-V, FLJ97995, MGC126836, RAP3MGC126838, Regeneration-associated protein 3

Entrez Gene IDs

116519 (Human)

Gene Symbol

APOA5

UniProt

Q6Q788 (Human)

Additional Apolipoprotein A5 Products

Product Documents for Apolipoprotein A5 Antibody (4H8H8E2) - BSA Free

Certificate of Analysis

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Product Specific Notices for Apolipoprotein A5 Antibody (4H8H8E2) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Apolipoprotein A5 Antibody (4H8H8E2) - BSA Free

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