AR-C 118925XX

Key Product Details

Product Description

AR-C 118925XX is a potent, selective, competitive and reversible P2Y₂ receptor antagonist (pA₂ = 8.43). Inactive against a panel of 37 other receptors at a concentration of 10 μM. AR-C 118925XX inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC₅₀ = 1 μM). Inhibits P2Y₂ receptor-induced β-arrestin translocation in vitro (pA₂ = 37.2-51.3 nM).

Product Specifications for AR-C 118925XX

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AR-C 118925XX

The following data is based on the product molecular weight 537.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.30 mL	18.60 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 56 publications citing the usage of this product.

• Muoboghare Characterisation of P2Y₂ receptors in human vascular endothelial cells using AR-C118925XX, a competitive and selective P2Y₂ antagonist. Br.J.Pharmacol. 2019 PMID: 31116875
• Meghani The design of P2Y₂ antagonists for the treatment of inflammatory diseases. Abstract of papers, 224th ACS National Meeting, Boston, MA
• Rafehi Synthesis, characterization, and in vitro evaluation of the selective P2Y₂ receptor antagonist AR-C118925. Purinergic.Signal. 2017 PMID: 27766552
• Kemp Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells. Am.J.Respir.Cell Mol.Biol. 2004 PMID: 15231488

Product Documents for AR-C 118925XX