Catalog Number: 4890
Chemical Name: 5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide
Biological Activity
Selective, competitive P2Y2 receptor antagonist. Inactive against a panel of 37 other receptors at a concentration of 10 μM. Inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). Inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM).
Technical Data
  • M.Wt:
    537.59
  • Formula:
    C28H23N7O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    216657-60-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells.
    Kemp et al.
    Am.J.Respir.Cell Mol.Biol., 2004;31:446
  2. The design of P2Y2 antagonists for the treatment of inflammatory diseases.
    Meghani
    Abstract of papers, 224th ACS National Meeting, Boston, MA, 2002;
  3. Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925.
    Rafehi et al.
    Purinergic.Signal., 2017;13:89

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