AR-C 118925XX

Catalog # Availability Size / Price Qty
4890/5
AR-C 118925XX | CAS No. 216657-60-2 | P2Y Receptor Antagonists
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Description: Selective and competitive P2Y2 antagonist

Chemical Name: 5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide

Purity: ≥97%

Product Details
Citations (6)
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Reviews

Biological Activity

Selective, competitive P2Y2 receptor antagonist. Inactive against a panel of 37 other receptors at a concentration of 10 μM. Inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). Inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM).

Technical Data

M.Wt:
537.59
Formula:
C28H23N7O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
216657-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925.
    Rafehi et al.
    Purinergic.Signal., 2017;13:89
  2. Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells.
    Kemp et al.
    Am.J.Respir.Cell Mol.Biol., 2004;31:446
  3. The design of P2Y2 antagonists for the treatment of inflammatory diseases.
    Meghani
    Abstract of papers, 224th ACS National Meeting, Boston, MA, 2002;

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