AR-C 118925XX

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AR-C 118925XX | CAS No. 216657-60-2 | P2Y Receptor Antagonists
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Description: Selective and competitive P2Y2 antagonist

Chemical Name: 5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide

Purity: ≥97%

Product Details
Citations (7)
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Biological Activity

AR-C 118925XX is a potent, selective, competitive and reversible P2Y2 receptor antagonist (pA2 = 8.43). Inactive against a panel of 37 other receptors at a concentration of 10 μM. AR-C 118925XX inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). Inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM).

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Background References

  1. Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925.
    Rafehi et al.
    Purinergic.Signal., 2017;13:89
  2. Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells.
    Kemp et al.
    Am.J.Respir.Cell Mol.Biol., 2004;31:446
  3. The design of P2Y2 antagonists for the treatment of inflammatory diseases.
    Abstract of papers, 224th ACS National Meeting, Boston, MA, 2002;

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