ARC/NOL3 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-76460

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all ARC Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Nop30. The immunogen is located within the last 50 amino acids of Nop30. Amino Acid Squence: SPKIPEGQSSDRRC

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ARC/NOL3 Antibody - BSA Free

Western Blot: ARC/NOL3 AntibodyBSA Free [NBP1-76460]

Western Blot: ARC/NOL3 AntibodyBSA Free [NBP1-76460]

Western Blot: ARC/NOL3 Antibody [NBP1-76460] - Mouse muscle tissue lysate with Nop30 antibody at (A) 0.5, (B) 1 and (C) 2 u/mL.

Applications for ARC/NOL3 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ARC

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and the caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. An alternate splicing isoform of ARC was identified as Nop30. While ARC interacts with caspase-2 and –8 and suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3, Nop30 multimerizes and binds to the splicing factor SRp30c and may act to influence alternative splice site selection in vivo. The Nop30 antibody will not detect ARC protein.

Long Name

Apoptosis Repressor with Caspase Recruitment Domain

Alternate Names

NOL3

Gene Symbol

NOL3

UniProt

AAH12798 (Human)

Additional ARC Products

Product Documents for ARC/NOL3 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for ARC/NOL3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cysteine Proteases and Regulators

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FAQs

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Associated Pathways

Apoptosis Signaling Pathway Apoptosis Signaling Pathway Thumbnail