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AS 1949490

  ( 2 citations )    
Product Datasheet
Catalog Number:3718
Chemical Name:3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Product Details
Citations (2)
Reviews
Biological Activity
Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects.
Technical Data
  • M.Wt:
    371.88
  • Formula:
    C20H18ClNO2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    1203680-76-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AS 1949490 include:

2 Citations: Showing 1 - 2
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  1. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.
    Authors: Hughes Et al.
    Front Neurosci  2015;26:3867
  2. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
    Authors: Chang Et al.
    Mol Biol Cell  2014;62:296

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