Catalog Number: 3718
Chemical Name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Biological Activity
Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects.
Technical Data
  • M.Wt:
    371.88
  • Formula:
    C20H18ClNO2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    1203680-76-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes.
    Suwa et al.
    Eur.J.Pharmacol., 2010;642:177
  2. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.
    Suwa et al.
    Br.J.Pharmcol., 2009;158:879
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AS 1949490 include:

2 Citations: Showing 1 - 2
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  1. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.
    Authors: Hughes Et al.
    Front Neurosci 2015;26:3867
  2. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
    Authors: Chang Et al.
    Mol Biol Cell 2014;62:296

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