Chemical Name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Biological ActivitySelective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Also promotes increased BDNF mRNA levels in cultured cortical neurons and has memory enhancing and antidepressant effects in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
AS1949490, an inhibitor of 5'-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons.
Tsuneki et al.
Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes.
Suwa et al.
Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.
Suwa et al.
Citations for AS 1949490
The citations listed below are publications that use Tocris products. Selected citations for AS 1949490 include:
5 Citations: Showing 1 - 5
MetF. increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.
Authors: Polianskyte-Prause Et al.
FASEB J 2019;33:2858
FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
Authors: Hak Et al.
Nat Cell Biol 2018;20:1023
Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells.
Authors: Ghosh Et al.
J Cell Sci 2018;131
PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.
Authors: Hughes Et al.
Front Neurosci 2015;26:3867
Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
Authors: Chang Et al.
Mol Biol Cell 2014;62:296
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