Biological Activity Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at RT
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For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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