Chemical Name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Biological ActivityAS 1949490 is a selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Also promotes increased BDNF mRNA levels in cultured cortical neurons and has memory enhancing and antidepressant effects in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
AS1949490, an inhibitor of 5'-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons.
Tsuneki et al.
Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes.
Suwa et al.
Citations for AS 1949490
The citations listed below are publications that use Tocris products. Selected citations for AS 1949490 include:
5 Citations: Showing 1 - 5
MetF. increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.
Authors: Polianskyte-Prause Et al.
FASEB J 2019;33:2858
FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
Authors: Hak Et al.
Nat Cell Biol 2018;20:1023
Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells.
Authors: Ghosh Et al.
J Cell Sci 2018;131
PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.
Authors: Hughes Et al.
Front Neurosci 2015;26:3867
Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
Authors: Chang Et al.
Mol Biol Cell 2014;62:296
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