Potent and selective GlyT1 inhibitor (IC50
= 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801
-induced working memory deficits and PCP
-induced visual learning deficits in mice. Orally available and brain penetrant.
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A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's diseas
Harada et al.
The citations listed below are publications that use Tocris products. Selected citations for ASP 2535 include:
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