Chemical Name: 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
Biological ActivityASP 2535 is a potent and selective GlyT1 inhibitor (IC50 = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.
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Citation for ASP 2535
The citations listed below are publications that use Tocris products. Selected citations for ASP 2535 include:
1 Citation: Showing 1 - 1
Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.
Authors: Ostrovskaya Et al.
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