Catalog Number: 2391
Biological Activity
Potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying.
Technical Data
  • M.Wt:
    4041.69
  • Formula:
    C183H307N49O53
  • Sequence:
    DLSFHLLRKXIEIEKQEKEKQQAENNKLLLDLI

    (Modifications: Asp-1 = N-terminal Ac, Phe-4 = D-Phe, Leu-6 = α-methyl-Leu, X = Nle, Glu-24 = γ-Glu, Lys-27 = ε-Lys, Leu-32 = α-methyl-Leu, Lactam Bridge = Glu-24 - Lys-27)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    681260-70-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists.
    Rivier et al.
    J.Med.Chem., 2002;45:4737
  2. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupled sensitivity and determinants of CRF2 receptor selectivity.
    Hoare et al.
    Peptides, 2005;26:457
  3. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress.
    Henry et al.
    J.Neurosci., 2006;26:9142
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Astressin 2B include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration.
    Authors: Boyson Et al.
    J Neurosci 2014;34:6659
  2. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
    Authors: Kash Et al.
    Invest Ophthalmol Vis Sci 2008;28:13856

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