Biological ActivityPotent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying.
(Modifications: Asp-1 = N-terminal Ac, Phe-4 = D-Phe, Leu-6 = α-methyl-Leu, X = Nle, Glu-24 = γ-Glu, Lys-27 = ε-Lys, Leu-32 = α-methyl-Leu, Lactam Bridge = Glu-24 - Lys-27)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupled sensitivity and determinants of CRF2 receptor selectivity.
Hoare et al.
The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress.
Henry et al.
Potent and long-acting cortico. releasing factor (CRF) receptor 2 selective peptide competitive antagonists.
Rivier et al.
Citations for Astressin 2B
The citations listed below are publications that use Tocris products. Selected citations for Astressin 2B include:
8 Citations: Showing 1 - 8
Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents.
Authors: Li Et al.
Cell Death Dis 2018;9:682
Corticotropin-Releasing Factor Receptors Modulate OXT Release in the Dorsolateral Bed Nucleus of the Stria Terminalis (BNST) in Male Rats.
Authors: Martinon and Dabrowska
Front Neurosci 2018;12:183
Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.
Authors: Rodriguez Et al.
Cell Mol Gastroenterol Hepatol 2015;1:610
Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain.
Authors: Tran Et al.
Social stress and CRF-DA interactions in the VTA: role in long-term escalation of cocaine self-administration.
Authors: Boyson Et al.
J Neurosci 2014;34:6659
Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors.
Authors: Abdelhamid Et al.
Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
Authors: Silberman and Winder
DA enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
Authors: Kash Et al.
Invest Ophthalmol Vis Sci 2008;28:13856
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