Astressin 2B

  ( 6 citations )    
Product Datasheet
Catalog Number:2391
Chemical Name:
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying.
Technical Data
  • M.Wt:
    4041.69
  • Formula:
    C183H307N49O53
  • Sequence:
    DLSFHLLRKXIEIEKQEKEKQQAENNKLLLDLI

    (Modifications: Asp-1 = N-terminal Ac, Phe-4 = D-Phe, Leu-6 = α-methyl-Leu, X = Nle, Glu-24 = γ-Glu, Lys-27 = ε-Lys, Leu-32 = α-methyl-Leu, Lactam Bridge = Glu-24 - Lys-27)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    681260-70-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Astressin 2B include:

6 Citations: Showing 1 - 6
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  1. Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.
    Authors: Rodriguez Et al.
    Cell Mol Gastroenterol Hepatol  2015;1:610
  2. Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain.
    Authors: Tran Et al.
    Neuropsychopharmacology  2014;39:2633
  3. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration.
    Authors: Boyson Et al.
    J Neurosci  2014;34:6659
  4. Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors.
    Authors: Abdelhamid Et al.
    Neuropharmacology  2013;72:29
  5. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
    Authors: Silberman and Winder
    Neuropharmacology  2013;70:316
  6. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
    Authors: Kash Et al.
    Invest Ophthalmol Vis Sci  2008;28:13856

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