aTAG 4531

Tocris Bioscience | Catalog # 6971

Degrader of MTH1 fusion proteins for use within the aTAG system
Tocris Bioscience

Key Product Details

Description

Degrader of MTH1 fusion proteins for use within the aTAG system

Alternative Names

CFT 4531
View all TAG Degradation Platforms »

Product Description

aTAG 4531 is a degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat. No. 0652). Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications.

Mouse DMPK properties are provided in the supplementary file (see below).

MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in. See protocol for more information.

Licensing Information

Sold under license from C4 Therapeutics

Supplementary Information

Mouse DMPK properties are provided in the accompanying supplementary file.

Product Specifications for aTAG 4531

Molecular Weight

867.85

Formula

C46H39F2N9O7

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide

CAS Number

2412985-00-1

InChI Key

BNHRIFMLKOQTPS-UHFFFAOYNA-N

SMILES

O=C(NC1CC1)C2=C(C3=C(N=C2)C=C(F)C(C4=CC(F)=C(C=C4)C(NCCCCN5N=NC(COC6=C(C7=CC=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=C5)=O)=C3)NC9=CC=CC=C9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 86.78 100

Preparing Stock Solutions for aTAG 4531

The following data is based on the product molecular weight 867.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.52 mL
5 mM 0.23 mL 1.15 mL 2.30 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

There are currently no references for this product.

Product Documents for aTAG 4531

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for aTAG 4531

For research use only

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