ATC 0175 hydrochloride

Catalog # Availability Size / Price Qty
3346/10
3346/50
ATC 0175 hydrochloride | CAS No. 510733-97-8 | Melanin-concentrating Hormone Receptor Antagonists
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Description: MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist

Chemical Name: N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride

Purity: ≥98%

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Biological Activity

Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT2B and 5-HT1A receptors (IC50 values are 9.66 and 16.9 nM respectively).

Technical Data

M.Wt:
461.94
Formula:
C23H25F2N5O.HCl
Solubility:
Soluble to 10 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
510733-97-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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