ATC 0175 hydrochloride

Key Product Details

Product Description

ATC 0175 hydrochloride is a potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH₁) antagonist (IC₅₀ values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT_2B and 5-HT_1A receptors (IC₅₀ values are 9.66 and 16.9 nM respectively).

Product Specifications for ATC 0175 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ATC 0175 hydrochloride

The following data is based on the product molecular weight 461.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.66 mL	43.30 mL	86.59 mL
1.25 mM	1.73 mL	8.66 mL	17.32 mL
2.5 mM	0.87 mL	4.33 mL	8.66 mL
12.5 mM	0.17 mL	0.87 mL	1.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chaki ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 PMID: 16614734
• Chaki Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 2005 PMID: 15677346

Product Documents for ATC 0175 hydrochloride