CPT 11

Catalog # Availability Size / Price Qty
2688/10
2688/50
CPT 11 | CAS No. 100286-90-6 | DNA Topoisomerase Inhibitors
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Description: DNA topoisomerase I inhibitor; antitumor
Alternative Names: Irinotecan, Camptothecin 11

Chemical Name: (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684).

Technical Data

M.Wt:
623.14
Formula:
C33H38N4O6.HCl
Solubility:
Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
100286-90-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats.
    Kawato et al.
    J.Pharm.Pharmacol., 1993;45:444
  2. Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts.
    Vassal et al.
    Br.J.Cancer., 1996;74:537
  3. Activation and antitumour activity of CPT-11 in plasma esterase-deficient mice.
    Morton et al.
    Can.Chemother.Pharmacol., 2005;56:629

Product Datasheets

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Citation for CPT 11

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