Inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38
, Cat. No. 2684).
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All Tocris products are intended for laboratory research use only.
Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats.
Kawato et al.
Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts.
Vassal et al.
Activation and antitumour activity of CPT-11 in plasma esterase-deficient mice.
Morton et al.