CPT 11

Key Product Details

Product Description

CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684).

Product Specifications for CPT 11

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CPT 11

The following data is based on the product molecular weight 623.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.60 mL	8.02 mL	16.05 mL
5 mM	0.32 mL	1.60 mL	3.21 mL
10 mM	0.16 mL	0.80 mL	1.60 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Vassal Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br.J.Cancer. 1996 PMID: 8761367
• Morton Activation and antitumour activity of CPT-11 in plasma esterase-deficient mice. Can.Chemother.Pharmacol. 2005 PMID: 15918039
• Kawato Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. J.Pharm.Pharmacol. 1993 PMID: 8099964

Product Documents for CPT 11