AZD 8055

Tocris Bioscience | Catalog # 7840

Highly potent and selective mTOR inhibitor
Tocris Bioscience

Key Product Details

Description

Highly potent and selective mTOR inhibitor
View all mTOR Inhibitors »

Product Description

AZD 8055 is a highly potent, selective and ATP-competitive mTOR inhibitor (IC50 = 0.8 nM). Inhibits growth and induces autophagy in a range of cancer cell lines and xenografts, including NSCLC and glioblastoma (IC50 values are 20, 50 and 53 nM in H838, A549 and U87MG cell lines, respectively). Orally bioavailable.

Product Specifications for AZD 8055

Molecular Weight

465.55

Formula

C25H31N5O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

CAS Number

1009298-09-2

PubChem ID

25262965

InChI Key

KVLFRAWTRWDEDF-IRXDYDNUSA-N

SMILES

C[C@@H]1N(CCOC1)C2=NC(N3[C@H](COCC3)C)=NC4=C2C=CC(C5=CC(CO)=C(C=C5)OC)=N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.55 100
Ethanol 9.31 20

Preparing Stock Solutions for AZD 8055

The following data is based on the product molecular weight 465.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.30 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for AZD 8055

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZD 8055

For research use only

Related Research Areas

Autophagy

Customer Reviews for AZD 8055 (1)

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  • test
    Name: Kishor Pant
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Du145 and HepG2, Huh&
    Verified Customer | Posted 08/19/2025
    It's a potent inhibitor of mTOR. It can induce autophagy.
    AZD 8055 7840

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