Azurin p28 peptide
Description: Increases p53 levels; binds p53 and inhibits COP1-mediated ubiquitination of p53
Purity: ≥95%
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Biological Activity
Azurin p28 peptide is a 28 amino acid fragment of azurin (amino acids 50-77). The peptide is preferentially taken up by human breast cancer cell lines via caveolin-mediated endocytosis. Azurin p28 peptide binds wild-type and mutant p53 protein and inhibits E3 ligase COP1-mediated ubiquitination of p53 by >80%, resulting in decreased proteasomal degradation of p53. It induces cell cycle arrest in the G2/M phase leading to apoptosis. Azurin p28 peptide exhibits antiproliferative effects in human breast cancer cells in vitro and in vivo.Technical Data
M.Wt:
2914.2
Formula:
C122H197N31O47S2
Sequence:
LSTAADMQGVVTDGMASGLDKDYLKPDD
Solubility:
Soluble to 2 mg/ml in 0.01M PBS
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
897026-25-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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