Chemical Name: 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
Biological ActivityRAD51 recombinase inhibitor, exhibiting selectivity for human RAD51 over the E.coli homologue RecA (IC50 values are 27.4 μM and >250 μM, respectively). Inhibits homologous recombination and increases cellular sensitivity to DNA damage in vitro. Enhances the therapeutic effect of cisplatin (Cat. No. 2251) on tumor cells in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Identification of specific inhibitors of human RAD51 recombinase using high-throughputscreening.
Huang et al.
ACS Chem.Biol., 2011;6:682
Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
Huang et al.
A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to doxorubicin.
Alagpulinsa et al.
A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeuticagents in mouse xenografts.
Huang and Mazin
PLoS One, 2014;9:e100993
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