Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
Biological ActivitySelective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.
F 127 (Cat. No. 6253) for the solubilization of BAPTA AM is also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Enhanced release of prostacyclin from quin 2-loaded endothelial cells.
Raspe et al.
The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.
Tang et al.
Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin.
Heilporn et al.
Citations for BAPTA AM
The citations listed below are publications that use Tocris products. Selected citations for BAPTA AM include:
22 Citations: Showing 1 - 10
Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
Cell Rep 2017;21(4):1009
Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
Int J Cell Biol 2017;2017:1908310
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
Physiological Reports 2016;4:e13069
Voltage Dependence of a Neuromodulator-Activated Ionic Current.
Authors: Gray and Golowasch
Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.
Authors: Pozner Et al.
Front Mol Neurosci 2015;8:12
Variation in human cancer cell external phosphatidylserine is regulated by flippase activity and intracellular calcium.
Authors: Vallabhapurapu Et al.
Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
Authors: Azab Et al.
J Biol Chem 2015;6
Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium.
Authors: Chen Et al.
BMC Complement Altern Med 2015;5:18204
Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
Authors: Draganov Et al.
Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.
Authors: Pecze Et al.
MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
Authors: Wang Et al.
Mol Pharmacol 2015;290:168
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
Authors: Díaz Et al.
J Exp Med 2015;212:665
Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia.
Authors: Ahn Et al.
J Biol Chem 2015;15:202
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
Authors: Leoni Et al.
Sci Rep 2015;125:1215
L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.
Authors: Morais Et al.
PLoS One 2015;10:e0132569
TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
Authors: Pandya and Pillai
Sci Rep 2014;12:47
P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
Authors: Campwala Et al.
J Cell Sci 2014;127:4964
Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
Authors: Pal Et al.
J Biol Chem 2013;288:3265
Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.
Authors: Lee Et al.
Immunol Cell Biol 2012;90:601
Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
Authors: Kajiya Et al.
J Clin Biochem Nutr 2012;82:115
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Authors: Lee Et al.
J Clin Invest 2012;492:123
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BAPTA AM being a chelator has been used on our lab multiple times to induce apoptosis in cell cultures.Works great