Catalog # Availability Size / Price Qty
BAPTA AM | CAS No. 126150-97-8 | Buffers, Chelators and Reagents
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Description: Cell-permeable Ca2+ chelator

Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)

Purity: ≥95%

Product Details
Citations (28)

Biological Activity

BAPTA AM is a selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.

F 127 (Cat. No. 6253) for the solubilization of BAPTA AM is also available.

Technical Data

Soluble to 30 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Enhanced release of prostacyclin from quin 2-loaded endothelial cells.
    Raspe et al.
    Eur.J.Pharmacol., 1989;163:345
  2. The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.
    Tang et al.
    Biochem.Pharmacol., 2007;74:1596
  3. Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin.
    Heilporn et al.
    Bull.Soc.Chim.Belg., 1994;103:309

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Citations for BAPTA AM

The citations listed below are publications that use Tocris products. Selected citations for BAPTA AM include:

28 Citations: Showing 1 - 10

  1. Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2 ).
    Authors: Markovics Et al.
    J Cell Mol Med  2019;23:6203
  2. Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies.
    Authors: Miteva Et al.
    J Cell Biol  2019;
  3. Selective Role of RGS9-2 in Regulating Retrograde Synaptic Signaling of Indirect Pathway Medium Spiny Neurons in Dorsal Striatum.
    Authors: Song Et al.
    J Neurosci  2018;38:7120
  4. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
    Authors: Florea Et al.
    Oncotarget  2017;8:22876
  5. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels.
    Authors: Jantarajit Et al.
    Am J Physiol Cell Physiol  2017;313:C118
  6. Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
    Authors: Zhang Et al.
    J Exp Med  2017;214:2671
  7. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
    Authors: Barbaro
    Cell Rep  2017;21(4):1009
  8. Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
    Authors: Alvarez-Arce
    Int J Cell Biol  2017;2017:1908310
  9. ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
    Authors: Gong
    Cell  2017;169(2):286
  10. Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
    Authors: Ahmed
    Physiological Reports  2016;4:e13069
  11. Voltage Dependence of a Neuromodulator-Activated Ionic Current.
    Authors: Gray and Golowasch
    Eneuro  2016;3
  12. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.
    Authors: Pozner Et al.
    Front Mol Neurosci  2015;8:12
  13. Variation in human cancer cell external phosphatidylserine is regulated by flippase activity and intracellular calcium.
    Authors: Vallabhapurapu Et al.
    Oncotarget  2015;6:34375
  14. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    J Biol Chem  2015;6
  15. Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium.
    Authors: Chen Et al.
    BMC Complement Altern Med  2015;5:18204
  16. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    Nature  2015;5:16222
  17. Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.
    Authors: Pecze Et al.
    MBio  2015;290:28214
  18. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
    Authors: Wang Et al.
    Mol Pharmacol  2015;290:168
  19. Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
    Authors: Díaz Et al.
    J Exp Med  2015;212:665
  20. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia.
    Authors: Ahn Et al.
    J Biol Chem  2015;15:202
  21. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Authors: Leoni Et al.
    Sci Rep  2015;125:1215
  22. L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.
    Authors: Morais Et al.
    PLoS One  2015;10:e0132569
  23. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
    Sci Rep  2014;12:47
  24. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
    Authors: Campwala Et al.
    J Cell Sci  2014;127:4964
  25. Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
    Authors: Pal Et al.
    J Biol Chem  2013;288:3265
  26. Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.
    Authors: Lee Et al.
    Immunol Cell Biol  2012;90:601
  27. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
    Authors: Kajiya Et al.
    J Clin Biochem Nutr  2012;82:115
  28. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    J Clin Invest  2012;492:123


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