BAPTA AM

  ( 22 citations )    
Product Datasheet
Catalog Number:2787
Chemical Name:1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
Product Details
Citations (22)
Reviews
Biological Activity
Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.
Technical Data
  • M.Wt:
    764.68
  • Formula:
    C34H40N2O18
  • Solubility:
    Soluble to 30 mM in DMSO
  • Purity:
    >95
  • Storage:
    Store at -20°C
  • CAS No:
    126150-97-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BAPTA AM include:

22 Citations: Showing 1 - 10
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  1. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
    Authors: Barbaro
    Cell Rep  2017;21(4):1009
  2. Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
    Authors: Alvarez-Arce
    Int J Cell Biol  2017;2017:1908310
  3. ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
    Authors: Gong
    Cell  2017;169(2):286
  4. Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
    Authors: Ahmed
    Physiological Reports  2016;4:e13069
  5. Voltage Dependence of a Neuromodulator-Activated Ionic Current.
    Authors: Gray and Golowasch
    Eneuro  2016;3
  6. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.
    Authors: Pozner Et al.
    Front Mol Neurosci  2015;8:12
  7. Variation in human cancer cell external phosphatidylserine is regulated by flippase activity and intracellular calcium.
    Authors: Vallabhapurapu Et al.
    Oncotarget  2015;6:34375
  8. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    J Biol Chem  2015;6
  9. Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium.
    Authors: Chen Et al.
    BMC Complement Altern Med  2015;5:18204
  10. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    Nature  2015;5:16222
  11. Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.
    Authors: Pecze Et al.
    MBio  2015;290:28214
  12. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
    Authors: Wang Et al.
    Mol Pharmacol  2015;290:168
  13. Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
    Authors: Díaz Et al.
    J Exp Med  2015;212:665
  14. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia.
    Authors: Ahn Et al.
    J Biol Chem  2015;15:202
  15. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Authors: Leoni Et al.
    Sci Rep  2015;125:1215
  16. L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.
    Authors: Morais Et al.
    PLoS One  2015;10:e0132569
  17. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
    Sci Rep  2014;12:47
  18. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
    Authors: Campwala Et al.
    J Cell Sci  2014;127:4964
  19. Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
    Authors: Pal Et al.
    J Biol Chem  2013;288:3265
  20. Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.
    Authors: Lee Et al.
    Immunol Cell Biol  2012;90:601
  21. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
    Authors: Kajiya Et al.
    J Clin Biochem Nutr  2012;82:115
  22. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    J Clin Invest  2012;492:123
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