Catalog Number: 2787
Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
Biological Activity
Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 30 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Enhanced release of prostacyclin from quin 2-loaded endothelial cells.
    Raspe et al.
    Eur.J.Pharmacol., 1989;163:345
  2. The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.
    Tang et al.
    Biochem.Pharmacol., 2007;74:1596
  3. Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin.
    Heilporn et al.
    Bull.Soc.Chim.Belg., 1994;103:309

The citations listed below are publications that use Tocris products. Selected citations for BAPTA AM include:

Showing Results 1 - 10 of 15

  1. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.
    Authors: Pozner Et al.
    Front Mol Neurosci
  2. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    J Biol Chem
  3. Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium.
    Authors: Chen Et al.
    BMC Complement Altern Med
  4. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
  5. Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.
    Authors: Pecze Et al.
  6. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
    Authors: Wang Et al.
    Mol Pharmacol
  7. Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
    Authors: Díaz Et al.
    J Exp Med
  8. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia.
    Authors: Ahn Et al.
    J Biol Chem
  9. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Authors: Leoni Et al.
    Sci Rep
  10. L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.
    Authors: Morais Et al.
    PLoS One
  11. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
    Sci Rep
  12. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
    Authors: Campwala Et al.
    J Cell Sci
  13. Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
    Authors: Pal Et al.
    J Biol Chem
  14. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
    Authors: Kajiya Et al.
    J Clin Biochem Nutr
  15. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    J Clin Invest
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