BAPTA AM

Catalog # Availability Size / Price Qty
2787/25
Cat.No. 2787 - BAPTA AM | C34H40N2O18 | CAS No. 126150-97-8
1 Image
Description: Cell-permeable Ca2+ chelator

Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)

Purity: ≥95%

Product Details
Citations (22)
Reviews

Biological Activity

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.

F 127 (Cat. No. 6253) for the solubilization of BAPTA AM is also available.

Technical Data

M.Wt:
764.68
Formula:
C34H40N2O18
Solubility:
Soluble to 30 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
126150-97-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Enhanced release of prostacyclin from quin 2-loaded endothelial cells.
    Raspe et al.
    Eur.J.Pharmacol., 1989;163:345
  2. The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.
    Tang et al.
    Biochem.Pharmacol., 2007;74:1596
  3. Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin.
    Heilporn et al.
    Bull.Soc.Chim.Belg., 1994;103:309

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for BAPTA AM

The citations listed below are publications that use Tocris products. Selected citations for BAPTA AM include:

22 Citations: Showing 1 - 10

  1. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
    Authors: Barbaro
    Cell Rep  2017;21(4):1009
  2. Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
    Authors: Alvarez-Arce
    Int J Cell Biol  2017;2017:1908310
  3. ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
    Authors: Gong
    Cell  2017;169(2):286
  4. Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
    Authors: Ahmed
    Physiological Reports  2016;4:e13069
  5. Voltage Dependence of a Neuromodulator-Activated Ionic Current.
    Authors: Gray and Golowasch
    Eneuro  2016;3
  6. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.
    Authors: Pozner Et al.
    Front Mol Neurosci  2015;8:12
  7. Variation in human cancer cell external phosphatidylserine is regulated by flippase activity and intracellular calcium.
    Authors: Vallabhapurapu Et al.
    Oncotarget  2015;6:34375
  8. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    J Biol Chem  2015;6
  9. Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium.
    Authors: Chen Et al.
    BMC Complement Altern Med  2015;5:18204
  10. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    Nature  2015;5:16222
  11. Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.
    Authors: Pecze Et al.
    MBio  2015;290:28214
  12. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
    Authors: Wang Et al.
    Mol Pharmacol  2015;290:168
  13. Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
    Authors: Díaz Et al.
    J Exp Med  2015;212:665
  14. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia.
    Authors: Ahn Et al.
    J Biol Chem  2015;15:202
  15. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Authors: Leoni Et al.
    Sci Rep  2015;125:1215
  16. L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.
    Authors: Morais Et al.
    PLoS One  2015;10:e0132569
  17. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
    Sci Rep  2014;12:47
  18. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
    Authors: Campwala Et al.
    J Cell Sci  2014;127:4964
  19. Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
    Authors: Pal Et al.
    J Biol Chem  2013;288:3265
  20. Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.
    Authors: Lee Et al.
    Immunol Cell Biol  2012;90:601
  21. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
    Authors: Kajiya Et al.
    J Clin Biochem Nutr  2012;82:115
  22. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    J Clin Invest  2012;492:123

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for BAPTA AM

There are currently no reviews for this product. Be the first to review BAPTA AM and earn rewards!

Have you used BAPTA AM?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.