Potent and selective BRD1 and TAF1 inhibitor (IC50
values are 6-67 and 8-13 nM, respectively). Displays selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). Displays BRD1 and TAF1 inhibition in a NanoBRET cell assay. Inhibits binding of BRD1 and TAF1 to histone H4 (IC50
values are 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50
values are 825 nM and 1.4 μM, respectively).
External Portal InformationChemicalprobes.org
is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 299
is reviewed on the Chemical Probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 299 probe summary
on the SGC website.
Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.
Klein et al.
Benzoisoquinolinediones as potent and selective inhibitors of BRPF2 and TAF1/TAF1L bromodomains.
Bouche et al.