Chemical Name: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
Biological ActivityBAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.
External Portal InformationThe Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876.
Siebeneicher et al.
Citations for BAY 876
The citations listed below are publications that use Tocris products. Selected citations for BAY 876 include:
2 Citations: Showing 1 - 2
YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.
Authors: Ole Et al.
Dev Cell 2022;57:212-227.e8
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Authors: Jessica E Et al.
Fluids Barriers CNS 2022;19:10
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