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BAY 876

6199 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6199/5
6199/25
BAY 876 | CAS No. 1799753-84-6 | Glucose Transporter Inhibitors
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Description: Potent and selective GLUT1 inhibitor

Chemical Name: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide

Purity: ≥98%

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Biological Activity

BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. This compound is cell permeable and orally bioavailable.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.

Technical Data

M.Wt:
496.42
Formula:
C24H16F4N6O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1799753-84-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876.
    Siebeneicher et al.
    ChemMedChem., 2016;11:2261

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