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BAY 876

Catalog #: 6199
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6199/5
6199/25

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BAY 876 | CAS No. 1799753-84-6 | Glucose Transporter Inhibitors
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Description: Potent and selective GLUT1 inhibitor

Chemical Name: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.

Technical Data

M.Wt:
496.42
Formula:
C24H16F4N6O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1799753-84-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876.
    Siebeneicher et al.
    ChemMedChem., 2016;11:2261

Product Datasheets

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Citations for BAY 876

The citations listed below are publications that use Tocris products. Selected citations for BAY 876 include:

2 Citations: Showing 1 - 2

  1. YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.
    Authors: Ole Et al.
    Dev Cell  2022;57:212-227.e8
  2. Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
    Authors: Jessica E Et al.
    Fluids Barriers CNS  2022;19:10

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