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BAY 876

6199 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6199/5
6199/25
Glucose Transporter Inhibitors Small Molecule
1 Image
Description: Potent and selective GLUT1 inhibitor

Chemical Name: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent and selective GLUT1 inhibitor (IC50 = 2 nM). Displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). Induces cell death in hypoxic conditions in vitro. Inhibits glucose uptake by Hela-MaTu cells. Cell permeable and orally bioavailable.

Technical Data

M.Wt:
496.42
Formula:
C24H16F4N6O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1799753-84-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-876 probe summary on the SGC website.

Background References

  1. Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876.
    Siebeneicher et al.
    ChemMedChem., 2016;11:2261

Product Datasheets

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