Potent dual antagonist of TP/DP2
(CRTH2) prostanoid receptors (Ki
values are 4.3, 4.5 and > 10000 nM for hDP2
, hTP and hDP1
receptors respectively). Suppresses PGD2
-induced migration of human eosinophils (IC50
= 170 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung.
Sundstrom et al.
Ramatroban (BAY u3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor.
Ishizuka et al.
Cardiovasc.Drug Rev., 2004;22:71
Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.
Ulven and Kostenis