BGC 20-1531 hydrochloride

Key Product Details

Product Description

BGC 20-1531 hydrochloride is a high affinity and selective EP₄ antagonist (K_i = 3 nM). Exhibits >2500-fold selectivity for EP₄ over EP₂ and EP₃. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE₂-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.

Product Specifications for BGC 20-1531 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BGC 20-1531 hydrochloride

The following data is based on the product molecular weight 529.00.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.89 mL	9.45 mL	18.90 mL
5 mM	0.38 mL	1.89 mL	3.78 mL
10 mM	0.19 mL	0.95 mL	1.89 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sutton From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP₄ receptor. Bioorg.Med.Chem.Lett. 2014 PMID: 24703233

Product Documents for BGC 20-1531 hydrochloride