BGC 20-1531 hydrochloride
Chemical Name: 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
Biological ActivityBGC 20-1531 hydrochloride is a high affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Complete Your Experiment
From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor.
Sutton et al.
Citation for BGC 20-1531 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BGC 20-1531 hydrochloride include:
1 Citation: Showing 1 - 1
Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
Authors: Perkins Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for BGC 20-1531 hydrochloride
There are currently no reviews for this product. Be the first to review BGC 20-1531 hydrochloride and earn rewards!
Have you used BGC 20-1531 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image