High affinity NPY Y1
receptor antagonist (IC50
values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2
receptors. Inhibits NPY- and fasting-induced feeding in vivo
following central administration. Also antagonizes anxiolytic-like effects of NPY.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig.
Lecklin et al.
Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents.
Wieland et al.
Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test.
Sajdyk et al.
The citations listed below are publications that use Tocris products. Selected citations for BIBO 3304 trifluoroacetate include:
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