BIBO 3304 trifluoroacetate

Key Product Details

Product Description

BIBO 3304 trifluoroacetate is a high affinity NPY Y₁ receptor antagonist (IC₅₀ values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y₂, Y₄ and Y₅ receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.

Product Specifications for BIBO 3304 trifluoroacetate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BIBO 3304 trifluoroacetate

The following data is based on the product molecular weight 757.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.32 mL	6.60 mL	13.20 mL
5 mM	0.26 mL	1.32 mL	2.64 mL
10 mM	0.13 mL	0.66 mL	1.32 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 30 publications citing the usage of this product.

• Sajdyk Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur.J.Pharmacol. 1999 PMID: 10193650
• Lecklin Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 2002 PMID: 11959807
• Wieland Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br.J.Pharmacol. 1998 PMID: 9806339

Product Documents for BIBO 3304 trifluoroacetate