BIBO 3304 trifluoroacetate
Chemical Name: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate
Biological ActivityBIBO 3304 trifluoroacetate is a high affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig.
Lecklin et al.
Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents.
Wieland et al.
Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test.
Sajdyk et al.
Citations for BIBO 3304 trifluoroacetate
The citations listed below are publications that use Tocris products. Selected citations for BIBO 3304 trifluoroacetate include:
11 Citations: Showing 1 - 10
Photo-induced receptor confinement drives ligand-independent GPCR signaling.
Authors: Sanchez Et al.
Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD
Authors: Maymon Et al.
Elevated Neuropeptide Y in Endothelial Dysfunction Promotes Macrophage Infiltration and Smooth Muscle Foam Cell Formation.
Authors: Choi Et al.
Front Immunol 2019;10:1701
A Neural Circuit for the Suppression of Pain by a Competing Need State.
Authors: Alhadeff Et al.
Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
Authors: Martins Et al.
ASN Neuro 2015;7
Diurnal fluctuations in HPA and neuropeptide Y-ergic systems underlie differences in vulnerability to traumatic stress responses at different zeitgeber times.
Authors: Cohen Et al.
J Neurosci 2015;40:774
The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
Authors: Panaro Et al.
Deconstruction of a neural circuit for hunger.
Authors: Atasoy Et al.
Cell Metab 2012;488:172
Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem.
Authors: Chen Et al.
Am J Physiol Regul Integr Comp Physiol 2012;302:R1401
A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
Authors: Kojima Et al.
Br J Pharmacol 2012;167:1362
Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear.
Authors: Pickens Et al.
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