BIBO 3304 trifluoroacetate

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BIBO 3304 trifluoroacetate | CAS No. 2310085-85-7 | NPY Receptor Antagonists
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Description: Highly selective NPY Y1 receptor antagonist

Chemical Name: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate

Purity: ≥98%

Product Details
Citations (11)
Supplemental Products

Biological Activity

BIBO 3304 trifluoroacetate is a high affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for BIBO 3304 trifluoroacetate

The citations listed below are publications that use Tocris products. Selected citations for BIBO 3304 trifluoroacetate include:

11 Citations: Showing 1 - 10

  1. Photo-induced receptor confinement drives ligand-independent GPCR signaling.
    Authors: Sanchez Et al.
    Science  2021;371
  2. Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD
    Authors: Maymon Et al.
    Neuropharmacology  2019;162
  3. Elevated Neuropeptide Y in Endothelial Dysfunction Promotes Macrophage Infiltration and Smooth Muscle Foam Cell Formation.
    Authors: Choi Et al.
    Front Immunol  2019;10:1701
  4. A Neural Circuit for the Suppression of Pain by a Competing Need State.
    Authors: Alhadeff Et al.
    Cell  2018;173:140
  5. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
    Authors: Martins Et al.
    ASN Neuro  2015;7
  6. Diurnal fluctuations in HPA and neuropeptide Y-ergic systems underlie differences in vulnerability to traumatic stress responses at different zeitgeber times.
    Authors: Cohen Et al.
    J Neurosci  2015;40:774
  7. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
    Authors: Panaro Et al.
    Neuropsychopharmacology  2014;20:1018
  8. Deconstruction of a neural circuit for hunger.
    Authors: Atasoy Et al.
    Cell Metab  2012;488:172
  9. Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem.
    Authors: Chen Et al.
    Am J Physiol Regul Integr Comp Physiol  2012;302:R1401
  10. A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
    Authors: Kojima Et al.
    Br J Pharmacol  2012;167:1362


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