Catalog Number: 0130
Chemical Name: [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
Biological Activity
Classical GABAA antagonist. Methoiodide salt (Cat. No. 2503), Methobromide salt (Cat. No. 0109) and Methochloride salt (Cat. No. 0131) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Studies on the neuropharmacological activity of bicuculline and related compounds.
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    Brain Res., 1976;102:283
  3. GABA, bicuculline and central inhibition.
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  4. Multiplicity of GABAA-benzodiazepine receptors.
    Sieghart et al.
    TiPS, 1989;10:407
  5. Intracerebral site of convulsant action of bicuculline.
    Piredda et al.
    Life Sci., 1985;36:1295

The citations listed below are publications that use Tocris products. Selected citations for (+)-Bicuculline include:

Showing Results 1 - 10 of 66

  1. Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
    Authors: Dinamarca Et al.
  2. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.
    Authors: Robinson Et al.
    Front Cell Neurosci
  3. Glycine and GABAA receptors mediate tonic and phasic inhibitory processes that contribute to prepulse inhibition in the goldfish startle network.
    Authors: Curtin and Preuss
    Front Neural Circuits
  4. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Front Cell Neurosci
  5. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
    Authors: Lee Et al.
    Mol Brain
  6. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
    Authors: Telese Et al.
  7. Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3.
    Authors: Zimmermann Et al.
    Front Synaptic Neurosci
  8. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    Cell Death Dis
  9. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
    Authors: Ciani Et al.
    Nat Commun
  10. Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
    Authors: Morini Et al.
    Stem Cell Res Ther
  11. Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons.
    Authors: Quintana Et al.
    J Physiol
  12. Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons.
    Authors: Pappas Et al.
  13. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
    Authors: Puranam Et al.
    J Neurosci
  14. Developmental changes in synaptic distribution in arcuate nucleus neurons.
    Authors: Baquero Et al.
    J Neurosci
  15. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.
    Authors: Dubal Et al.
    J Neurosci
  16. Role of parafacial nuclei in control of breathing in adult rats.
    Authors: Huckstepp Et al.
    J Neurosci
  17. The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors.
    Authors: Ding Et al.
    J Psychopharmacol
  18. Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex.
    Authors: Wu Et al.
    J Biomed Sci
  19. Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
    Authors: John Et al.
    Brain Res
  20. The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA.
    Authors: Kangarlu-Haghighi Et al.
  21. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
    Authors: Bernard and Zhang
    PLoS One
  22. Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of η-subunit containing GABA ARs.
    Authors: Hengen Et al.
    PLoS One
  23. Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism.
    Authors: Chen Et al.
    Front Behav Neurosci
  24. Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
    Authors: Weston Et al.
    Front Mol Neurosci
  25. Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA.
    Authors: Suzuki Et al.
    Nat Commun
  26. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci
  27. Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
    Authors: Gaffaney Et al.
    Mol Biol Cell
  28. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
    Authors: Bemben Et al.
    Nat Neurosci
  29. Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice.
    Authors: Oostland Et al.
  30. GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
    Authors: Berlinguer-Palmini Et al.
    PLoS One
  31. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
    Authors: Medrihan Et al.
    Nat Commun
  32. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
    Authors: Chen Et al.
    J Neurosci
  33. Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
    Authors: Zemoura Et al.
    J Biol Chem
  34. Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
    Authors: Hou and Yu
    J Biol Chem
  35. Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord.
    Authors: Hur and Park
    Korean J Physiol Pharmacol
  36. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
    Authors: Korb Et al.
    Nat Neurosci
  37. Plasticity-related gene 3 promotes neurite shaft protrusion.
    Authors: Velmans Et al.
    BMC Neurosci
  38. Synaptic and extrasynaptic transmission of kidney-related neurons in the rostral ventrolateral medulla.
    Authors: Gao and Derbenev
    J Neurophysiol
  39. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    J Neurosci
  40. Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation.
    Authors: Yamamoto Et al.
    J Neurosci
  41. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
    Authors: Daftary Et al.
  42. Increased bursting glutamatergic neurotransmission in an auditory forebrain area of the zebra finch (Taenopygia guttata) induced by auditory stimulation.
    Authors: Dagostin Et al.
    J Comp Physiol A Neuroethol Sens Neural Behav Phys
  43. Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
    Authors: Yao Et al.
    Nat Neurosci
  44. Basolateral amygdala inactivation impairs learning-induced long-term potentiation in the cerebellar cortex.
    Authors: Zhu Et al.
    PLoS One
  45. Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.
    Authors: Uschakov Et al.
    PLoS One
  46. Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons.
    Authors: Porcher Et al.
    J Biol Chem
  47. Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways.
    Authors: Mou Et al.
  48. SV2 mediates entry of tetanus neurotoxin into central neurons.
    Authors: Yeh Et al.
    PLoS Pathog
  49. Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.
    Authors: Mah Et al.
    J Neurosci
  50. Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.
    Authors: Smejkalova and Woolley
    J Neurosci
  51. Cannabinoids excite circadian clock neurons.
    Authors: Acuna-Goycolea Et al.
    J Neurosci
  52. Imaging activity-dependent regulation of neurexin-neuroligin interactions using trans-synaptic enzymatic biotinylation.
    Authors: Thyagarajan and Ting
  53. Characterization of engineered channelrhodopsin variants with improved properties and kinetics.
    Authors: Lin Et al.
    Biophys J
  54. Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor.
    Authors: Young and Neher
  55. Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.
    Authors: Yeo Et al.
    J Neurosci
  56. Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission.
    Authors: Kuroyanagi Et al.
    Proc Natl Acad Sci U S A
  57. Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.
    Authors: Andäng Et al.
  58. Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice.
    Authors: Hong Et al.
    J Neurosci
  59. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
    Authors: Soriano Et al.
    J Neurosci
  60. Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus.
    Authors: Surges Et al.
    Eur J Neurosci
  61. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons.
    Authors: Riccio Et al.
    Mol Cell
  62. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    Authors: Lenz and Avruch
    J Biol Chem
  63. Distinct γ2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin.
    Authors: Alldred Et al.
    J Neurosci
  64. Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
    Authors: Ying and Goldstein
    Mol Pain
  65. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.
    Authors: Berghuis Et al.
    Proc Natl Acad Sci U S A
  66. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci
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