Chemical Name: [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
Biological Activity(+)-Bicuculline is a classical GABAA antagonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Studies on the neuropharmacological activity of bicuculline and related compounds.
Olsen et al.
Brain Res., 1976;102:283
GABA, bicuculline and central inhibition.
Curtis et al.
Intracerebral site of convulsant action of bicuculline.
Piredda et al.
Life Sci., 1985;36:1295
Multiplicity of GABAA-benzodiazepine receptors.
Sieghart et al.
Citations for (+)-Bicuculline
The citations listed below are publications that use Tocris products. Selected citations for (+)-Bicuculline include:
99 Citations: Showing 1 - 10
Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice
Authors: He Et al.
Cell Rep 2020;33
Sonic hedgehog expression in the postnatal brain.
Authors: Rivell Et al.
Biol Open 2019;8
Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Authors: Wagner Et al.
Cell Rep 2019;28:11
Modulation of Functional Connectivity Between DA Neurons of the Rat Ventral Tegmental Area in vitro.
Authors: Velden Et al.
Front Integr Neurosci 2019;13:20
AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
Authors: Marinangeli Et al.
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Authors: Zhang Et al.
JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory.
Authors: Morel Et al.
J Neurosci 2018;38:3708
The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.
Authors: McKay Et al.
Cell Rep 2018;25:841
Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
δ-subunit containing GABAA receptors modulate respiratory networks.
Sci Rep 2017;7(1):18105
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.
Authors: Leal Et al.
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Authors: Li Et al.
Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
Authors: Imlach Et al.
Scientific Reports 2016;6:37104
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
Authors: Dinamarca Et al.
Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations.
Authors: Datta Et al.
γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.
Authors: Brown Et al.
J Biol Chem 2016;291:13926
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
Authors: Acuña Et al.
J Clin Invest 2016;126:2547
Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.
Authors: Robinson Et al.
Front Cell Neurosci 2015;9:404
Glycine and GABAA receptors mediate tonic and phasic inhibitory processes that contribute to prepulse inhibition in the goldfish startle network.
Authors: Curtin and Preuss
Front Neural Circuits 2015;9:12
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
Authors: Campbell Et al.
Front Cell Neurosci 2015;8:425
N-MthD.-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
Authors: Lee Et al.
Mol Brain 2015;8:4
LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
Authors: Telese Et al.
Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3.
Authors: Zimmermann Et al.
Front Synaptic Neurosci 2015;7:16
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
Authors: Curcio Et al.
Cell Death Dis 2015;6:e1645
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Authors: Ciani Et al.
Nat Commun 2015;6:8302
Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
Authors: Morini Et al.
Stem Cell Res Ther 2015;6:166
Synaptic structure and function are altered by the neddylation inhibitor MLN4924.
Authors: Scudder and Patrick
Mol Cell Neurosci 2015;65:52
Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons.
Authors: Quintana Et al.
J Physiol 2015;593:4373
Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons.
Authors: Pappas Et al.
α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Ins in Cerebellar Granule Cells.
Authors: Accardi Et al.
J Neurosci 2015;35:9676
Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
Authors: Puranam Et al.
J Neurosci 2015;35:8866
Developmental changes in synaptic distribution in arcuate nucleus neurons.
Authors: Baquero Et al.
J Neurosci 2015;35:8558
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.
Authors: Dubal Et al.
J Neurosci 2015;35:2358
Role of parafacial nuclei in control of breathing in adult rats.
Authors: Huckstepp Et al.
J Neurosci 2015;35:1052
The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors.
Authors: Ding Et al.
J Psychopharmacol 2015;29:725
Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex.
Authors: Wu Et al.
J Biomed Sci 2015;22:94
Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
Authors: John Et al.
Brain Res 2015;1601:15
The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA.
Authors: Kangarlu-Haghighi Et al.
EXCLI J 2015;14:613
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
Authors: Bernard and Zhang
PLoS One 2015;10:e0124816
Daily isofl. exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of η-subunit containing GABA ARs.
Authors: Hengen Et al.
PLoS One 2015;10:e0119351
Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism.
Authors: Chen Et al.
Front Behav Neurosci 2014;8:219
Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
Authors: Weston Et al.
Front Mol Neurosci 2014;7:1
Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA.
Authors: Suzuki Et al.
Nat Commun 2014;5:4153
Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission.
Authors: Accardi Et al.
Nat Commun 2014;5:3168
Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
Authors: Lee Et al.
Philos Trans R Soc Lond B Biol Sci 2014;369:20130158
Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
Authors: Verstegen Et al.
J Neurosci 2014;34:7266
Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
Authors: Gaffaney Et al.
Mol Biol Cell 2014;25:481
CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
Authors: Bemben Et al.
Nat Neurosci 2014;17:56
Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice.
Authors: Oostland Et al.
GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
Authors: Berlinguer-Palmini Et al.
PLoS One 2013;8:e82180
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Authors: Koeglsperger Et al.
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
Authors: Medrihan Et al.
Nat Commun 2013;4:1512
Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states.
Authors: Deeb Et al.
Eur J Neurosci 2013;38:2453
The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
Authors: Chen Et al.
J Neurosci 2013;33:8336
Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
Authors: Zemoura Et al.
J Biol Chem 2013;288:34897
Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
Authors: Hou and Yu
J Biol Chem 2013;288:2501
Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord.
Authors: Hur and Park
Korean J Physiol Pharmacol 2013;17:553
Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
Authors: Korb Et al.
Nat Neurosci 2013;16:874
Plasticity-related gene 3 promotes neurite shaft protrusion.
Authors: Velmans Et al.
BMC Neurosci 2013;14:36
Synaptic and extrasynaptic transmission of kidney-related neurons in the rostral ventrolateral medulla.
Authors: Gao and Derbenev
J Neurophysiol 2013;110:2637
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
Authors: Kaufman Et al.
J Neurosci 2012;32:3992
Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation.
Authors: Yamamoto Et al.
J Neurosci 2012;32:14254
Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission.
Authors: Weston Et al.
J Neurosci 2012;32:11441
Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
Authors: Daftary Et al.
Increased bursting glutamatergic neurotransmission in an auditory forebrain area of the zebra finch (Taenopygia guttata) induced by auditory stimulation.
Authors: Dagostin Et al.
J Comp Physiol A Neuroethol Sens Neural Behav Phys 2012;198:705
Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
Authors: Yao Et al.
Nat Neurosci 2012;15:243
Basolateral amygdala inactivation impairs learning-induced long-term potentiation in the cerebellar cortex.
Authors: Zhu Et al.
PLoS One 2011;6:e16673
Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.
Authors: Uschakov Et al.
PLoS One 2011;6:e16672
Potentiating action of PropF. at GABAA receptors of retinal bipolar cells.
Authors: Yue Et al.
Invest Ophthalmol Vis Sci 2011;52:2497
Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons.
Authors: Porcher Et al.
J Biol Chem 2011;286:21667
Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways.
Authors: Mou Et al.
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Authors: Gangadharan Et al.
J Clin Invest 2011;121:1608
SV2 mediates entry of tetanus neurotoxin into central neurons.
Authors: Yeh Et al.
PLoS Pathog 2010;6:e1001207
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Authors: Zhao Et al.
J Physiol 2010;588:2605
Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.
Authors: Mah Et al.
J Neurosci 2010;30:5559
OE acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.
Authors: Smejkalova and Woolley
J Neurosci 2010;30:16137
Cannabinoids excite circadian clock neurons.
Authors: Acuna-Goycolea Et al.
J Neurosci 2010;30:10061
Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction.
Authors: Han Et al.
Am J Physiol Regul Integr Comp Physiol 2010;299:R129
Imaging activity-dependent regulation of neurexin-neuroligin interactions using trans-synaptic enzymatic biotinylation.
Authors: Thyagarajan and Ting
Characterization of engineered channelrhodopsin variants with improved properties and kinetics.
Authors: Lin Et al.
Biophys J 2009;96:1803
Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor.
Authors: Young and Neher
Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.
Authors: Yeo Et al.
J Neurosci 2009;29:14652
Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model.
Authors: Zhang Et al.
Brain Res 2009;1247:196
Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission.
Authors: Kuroyanagi Et al.
Proc Natl Acad Sci U S A 2009;106:4912
Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.
Authors: Andäng Et al.
Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice.
Authors: Hong Et al.
J Neurosci 2008;28:13003
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
Authors: Soriano Et al.
J Neurosci 2008;28:10696
Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation.
Authors: Zhang Et al.
Exp Neurol 2008;212:44
Transient allodynia pain models in mice for early assessment of analgesic activity.
Authors: Gil Et al.
Br J Pharmacol 2008;153:769
Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
Authors: Brager and Johnston
J Neurosci 2007;27:13926
Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus.
Authors: Surges Et al.
Eur J Neurosci 2006;24:94
A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons.
Authors: Riccio Et al.
Mol Cell 2006;21:283
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
Authors: Lenz and Avruch
J Biol Chem 2005;280:38121
Distinct γ2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin.
Authors: Alldred Et al.
J Neurosci 2005;25:594
PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
Authors: Ying and Goldstein
Mol Pain 2005;1:2
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.
Authors: Berghuis Et al.
Proc Natl Acad Sci U S A 2005;102:19115
Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
Authors: Huang Et al.
J Neurosci 2004;24:4551
D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices.
Authors: Rouaud and Billard
Br J Pharmacol 2003;140:1051
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus.
Authors: Krucker Et al.
Proc Natl Acad Sci U S A 2000;97:6856
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
VersaClone cDNA Plasmids
Reviews for (+)-Bicuculline
Average Rating: 5 (Based on 1 Review)
Have you used (+)-Bicuculline?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
We have used (+)-Bicuculline (BIC) as a control tool to make sure that only GABA-A receptors are active under perfusion with given set of neuroreceptor antagonists.Being applied at membrane patches excised from cerebellar granule cell, 10 microM GABA triggered clear single-channel openings of GABA-A receptors. However, 100 microM BIC added together with GABA completely suppressed all single-channel activity, thus proving absence of other receptor types.