Chemical Name: [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
Biological ActivityClassical GABAA antagonist.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Studies on the neuropharmacological activity of bicuculline and related compounds.
Olsen et al.
Brain Res., 1976;102:283
GABA, bicuculline and central inhibition.
Curtis et al.
Intracerebral site of convulsant action of bicuculline.
Piredda et al.
Life Sci., 1985;36:1295
Multiplicity of GABAA-benzodiazepine receptors.
Sieghart et al.
Citations for (+)-Bicuculline
The citations listed below are publications that use Tocris products. Selected citations for (+)-Bicuculline include:
99 Citations: Showing 1 - 10
Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice
Authors: He Et al.
Cell Rep 2020;33
Sonic hedgehog expression in the postnatal brain.
Authors: Rivell Et al.
Biol Open 2019;8
Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Authors: Wagner Et al.
Cell Rep 2019;28:11
Modulation of Functional Connectivity Between DA Neurons of the Rat Ventral Tegmental Area in vitro.
Authors: Velden Et al.
Front Integr Neurosci 2019;13:20
AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
Authors: Marinangeli Et al.
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Authors: Zhang Et al.
JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory.
Authors: Morel Et al.
J Neurosci 2018;38:3708
The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.
Authors: McKay Et al.
Cell Rep 2018;25:841
Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
δ-subunit containing GABAA receptors modulate respiratory networks.
Sci Rep 2017;7(1):18105
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.
Authors: Leal Et al.
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Authors: Li Et al.
Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
Authors: Imlach Et al.
Scientific Reports 2016;6:37104
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
Authors: Dinamarca Et al.
Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations.
Authors: Datta Et al.
γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.
Authors: Brown Et al.
J Biol Chem 2016;291:13926
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
Authors: Acuña Et al.
J Clin Invest 2016;126:2547
Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.
Authors: Robinson Et al.
Front Cell Neurosci 2015;9:404
Glycine and GABAA receptors mediate tonic and phasic inhibitory processes that contribute to prepulse inhibition in the goldfish startle network.
Authors: Curtin and Preuss
Front Neural Circuits 2015;9:12
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
Authors: Campbell Et al.
Front Cell Neurosci 2015;8:425
N-MthD.-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
Authors: Lee Et al.
Mol Brain 2015;8:4
LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
Authors: Telese Et al.
Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3.
Authors: Zimmermann Et al.
Front Synaptic Neurosci 2015;7:16
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
Authors: Curcio Et al.
Cell Death Dis 2015;6:e1645
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Authors: Ciani Et al.
Nat Commun 2015;6:8302
Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
Authors: Morini Et al.
Stem Cell Res Ther 2015;6:166
Synaptic structure and function are altered by the neddylation inhibitor MLN4924.
Authors: Scudder and Patrick
Mol Cell Neurosci 2015;65:52
Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons.
Authors: Quintana Et al.
J Physiol 2015;593:4373
Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons.
Authors: Pappas Et al.
α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Ins in Cerebellar Granule Cells.
Authors: Accardi Et al.
J Neurosci 2015;35:9676
Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
Authors: Puranam Et al.
J Neurosci 2015;35:8866
Developmental changes in synaptic distribution in arcuate nucleus neurons.
Authors: Baquero Et al.
J Neurosci 2015;35:8558
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.
Authors: Dubal Et al.
J Neurosci 2015;35:2358
Role of parafacial nuclei in control of breathing in adult rats.
Authors: Huckstepp Et al.
J Neurosci 2015;35:1052
The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors.
Authors: Ding Et al.
J Psychopharmacol 2015;29:725
Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex.
Authors: Wu Et al.
J Biomed Sci 2015;22:94
Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
Authors: John Et al.
Brain Res 2015;1601:15
The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA.
Authors: Kangarlu-Haghighi Et al.
EXCLI J 2015;14:613
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
Authors: Bernard and Zhang
PLoS One 2015;10:e0124816
Daily isofl. exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of η-subunit containing GABA ARs.
Authors: Hengen Et al.
PLoS One 2015;10:e0119351
Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism.
Authors: Chen Et al.
Front Behav Neurosci 2014;8:219
Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
Authors: Weston Et al.
Front Mol Neurosci 2014;7:1
Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA.
Authors: Suzuki Et al.
Nat Commun 2014;5:4153
Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission.
Authors: Accardi Et al.
Nat Commun 2014;5:3168
Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
Authors: Lee Et al.
Philos Trans R Soc Lond B Biol Sci 2014;369:20130158
Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
Authors: Verstegen Et al.
J Neurosci 2014;34:7266
Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
Authors: Gaffaney Et al.
Mol Biol Cell 2014;25:481
CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
Authors: Bemben Et al.
Nat Neurosci 2014;17:56
Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice.
Authors: Oostland Et al.
GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
Authors: Berlinguer-Palmini Et al.
PLoS One 2013;8:e82180
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Authors: Koeglsperger Et al.
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
Authors: Medrihan Et al.
Nat Commun 2013;4:1512
Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states.
Authors: Deeb Et al.
Eur J Neurosci 2013;38:2453
The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
Authors: Chen Et al.
J Neurosci 2013;33:8336
Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
Authors: Zemoura Et al.
J Biol Chem 2013;288:34897
Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
Authors: Hou and Yu
J Biol Chem 2013;288:2501
Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord.
Authors: Hur and Park
Korean J Physiol Pharmacol 2013;17:553
Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
Authors: Korb Et al.
Nat Neurosci 2013;16:874
Plasticity-related gene 3 promotes neurite shaft protrusion.
Authors: Velmans Et al.
BMC Neurosci 2013;14:36
Synaptic and extrasynaptic transmission of kidney-related neurons in the rostral ventrolateral medulla.
Authors: Gao and Derbenev
J Neurophysiol 2013;110:2637
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
Authors: Kaufman Et al.
J Neurosci 2012;32:3992
Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation.
Authors: Yamamoto Et al.
J Neurosci 2012;32:14254
Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission.
Authors: Weston Et al.
J Neurosci 2012;32:11441
Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
Authors: Daftary Et al.
Increased bursting glutamatergic neurotransmission in an auditory forebrain area of the zebra finch (Taenopygia guttata) induced by auditory stimulation.
Authors: Dagostin Et al.
J Comp Physiol A Neuroethol Sens Neural Behav Phys 2012;198:705
Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
Authors: Yao Et al.
Nat Neurosci 2012;15:243
Basolateral amygdala inactivation impairs learning-induced long-term potentiation in the cerebellar cortex.
Authors: Zhu Et al.
PLoS One 2011;6:e16673
Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.
Authors: Uschakov Et al.
PLoS One 2011;6:e16672
Potentiating action of PropF. at GABAA receptors of retinal bipolar cells.
Authors: Yue Et al.
Invest Ophthalmol Vis Sci 2011;52:2497
Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons.
Authors: Porcher Et al.
J Biol Chem 2011;286:21667
Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways.
Authors: Mou Et al.
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Authors: Gangadharan Et al.
J Clin Invest 2011;121:1608
SV2 mediates entry of tetanus neurotoxin into central neurons.
Authors: Yeh Et al.
PLoS Pathog 2010;6:e1001207
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Authors: Zhao Et al.
J Physiol 2010;588:2605
Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.
Authors: Mah Et al.
J Neurosci 2010;30:5559
OE acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.
Authors: Smejkalova and Woolley
J Neurosci 2010;30:16137
Cannabinoids excite circadian clock neurons.
Authors: Acuna-Goycolea Et al.
J Neurosci 2010;30:10061
Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction.
Authors: Han Et al.
Am J Physiol Regul Integr Comp Physiol 2010;299:R129
Imaging activity-dependent regulation of neurexin-neuroligin interactions using trans-synaptic enzymatic biotinylation.
Authors: Thyagarajan and Ting
Characterization of engineered channelrhodopsin variants with improved properties and kinetics.
Authors: Lin Et al.
Biophys J 2009;96:1803
Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor.
Authors: Young and Neher
Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.
Authors: Yeo Et al.
J Neurosci 2009;29:14652
Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model.
Authors: Zhang Et al.
Brain Res 2009;1247:196
Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission.
Authors: Kuroyanagi Et al.
Proc Natl Acad Sci U S A 2009;106:4912
Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.
Authors: Andäng Et al.
Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice.
Authors: Hong Et al.
J Neurosci 2008;28:13003
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
Authors: Soriano Et al.
J Neurosci 2008;28:10696
Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation.
Authors: Zhang Et al.
Exp Neurol 2008;212:44
Transient allodynia pain models in mice for early assessment of analgesic activity.
Authors: Gil Et al.
Br J Pharmacol 2008;153:769
Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
Authors: Brager and Johnston
J Neurosci 2007;27:13926
Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus.
Authors: Surges Et al.
Eur J Neurosci 2006;24:94
A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons.
Authors: Riccio Et al.
Mol Cell 2006;21:283
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
Authors: Lenz and Avruch
J Biol Chem 2005;280:38121
Distinct γ2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin.
Authors: Alldred Et al.
J Neurosci 2005;25:594
PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
Authors: Ying and Goldstein
Mol Pain 2005;1:2
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.
Authors: Berghuis Et al.
Proc Natl Acad Sci U S A 2005;102:19115
Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
Authors: Huang Et al.
J Neurosci 2004;24:4551
D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices.
Authors: Rouaud and Billard
Br J Pharmacol 2003;140:1051
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus.
Authors: Krucker Et al.
Proc Natl Acad Sci U S A 2000;97:6856
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We have used (+)-Bicuculline (BIC) as a control tool to make sure that only GABA-A receptors are active under perfusion with given set of neuroreceptor antagonists.Being applied at membrane patches excised from cerebellar granule cell, 10 microM GABA triggered clear single-channel openings of GABA-A receptors. However, 100 microM BIC added together with GABA completely suppressed all single-channel activity, thus proving absence of other receptor types.