Human GABA-A R delta (NP_000806) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Human GABA-A R delta (NP_000806) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: GABA-A R delta

GABA A (γ-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABA A receptors are heteropentamer combinations of seven subunit types; α, β, γ, δ, ε, θ, and π. Three subunits, α, β, and γ, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of α, β, and γ subunits.

In select neurons, however, a δ subunit replaces the γ subunit. It would appear that δ subunits have a preference for various α-β combinations. In cerebellar granule cells, the δsubunit contributes to a unique α6/β/δ heteromer. δ subunit receptors may function to limit the spread of excitatory impulses to dendritically-complexed neurons. They also appear to be sensitive to steroid modulation. The rat δ subunit is a 50 kDa, 433 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 4 - 246). The rat and mouse N-terminal extracellular domains (ECD) (aa 17 - 248) are 99% aa identical; the mouse and human ECD are 95% aa identical.

Long Name
gamma-Aminobutyric Acid Type A Receptor, delta Polypeptide
Entrez Gene IDs
2563 (Human); 14403 (Mouse); 29689 (Rat)
Alternate Names
EIG10; EJM7; GABA A R delta; GABA(A) receptor subunit delta; GABA-A receptor, delta polypeptide; GABAAR delta; GABAARd; GABRD; gamma-aminobutyric acid (GABA) A receptor, delta; gamma-aminobutyric acid receptor subunit delta; GEFSP5; MGC45284


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