Human GABA-A R beta 1 (NP_000803) VersaClone cDNA Summary
Complete Your Research
Complete Your Experiment
Background: GABA-A R beta 1
GABA A (γ-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABA A receptors are heteropentamer combinations of seven subunit types; α, β, γ, δ, ε, θ, and π. Three subunits, α, β, and γ, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of α, β, and γ subunits.
The rat β1 isoform is a 58 - 60 kDa, 449 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 13 - 218). The β1 subunit is known to be phosphorylated on a consensus phosphorylation site (S409 of the precursor) that exists in the cytoplasmic domain between transmembrane segments 3 and 4. PKA or PKC βII-induced phosphorylation decreases GABA A receptor activity.
No product specific FAQs exist for this product, however you mayView all cDNA Clone FAQs
Tocris Small Molecules
Reviews for Human GABA-A R beta 1 (NP_000803) VersaClone cDNA
There are currently no reviews for this product. Be the first to review Human GABA-A R beta 1 (NP_000803) VersaClone cDNA and earn rewards!
Have you used Human GABA-A R beta 1 (NP_000803) VersaClone cDNA?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image