Human GABA-A R alpha 6 (NP_000802) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Human GABA-A R alpha 6 (NP_000802) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: GABA-A R alpha 6

GABA A (γ-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABA A receptors are heteropentamer combinations of seven subunit types; α, β, γ, δ, ε, θ, and π. Three subunits, α, β, and γ, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of α, β, and γ subunits.

The rat α6 isoform is a 57 kDa, 434 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 14 - 221). The expression of the α6 subunit is strongly associated with cerebellar granule cells. The α6 subunit has also been linked to alcohol sensitivity, possible due to a point mutation substitution of arginine for a glutamine at amino acid position 81 in the extracellular N-terminus.

Long Name
gamma-Aminobutyric Acid Type A Receptor, alpha-6 Polypeptide
Entrez Gene IDs
2559 (Human); 14399 (Mouse); 29708 (Rat)
Alternate Names
GABA A R alpha 6; GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6; GABAAR alpha 6; GABAARa6; GABRA6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid receptor subunit alpha-6; MGC116903; MGC116904


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