BIIE 0246

Name: BIIE 0246
Brand: Tocris Bioscience
SKU: 1700

Tocris Bioscience | Catalog # 1700

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Citations (95)

Product Documents

Potent, selective non-peptide NPY Y2 receptor antagonist

Discontinued Product

1700 has been discontinued. An alternative/replacement product is available: 7377. View all NPY Receptor Antagonists products.

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent, selective non-peptide NPY Y2 receptor antagonist

View all NPY Receptor Antagonists »

Product Description

Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y₂ receptor (IC₅₀ = 15 nM). Displays > 650-fold selectivity over Y₁, Y₄ and Y₅ receptors. Active in vivo.

Product Specifications for BIIE 0246

Molecular Weight

896.06

Formula

C₄₉H₅₇N₁₁O₆

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide

CAS Number

246146-55-4

PubChem ID

2690

InChI Key

MSJODEOZODDVGW-UHFFFAOYSA-N

SMILES

O=C(C4=C3C=CC=C4)NC1=CC=CC=C1C3N(CC2)CCN2C(CC5(CCCC5)CC(N[C@@H](CCCNC(N)=N)C(NCCN6C(N(C7=CC=CC=C7)N(C8=CC=CC=C8)C6=O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	67.2	75
	Ethanol	23.55	25

Preparing Stock Solutions for BIIE 0246

The following data is based on the product molecular weight 896.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	1.49 mL	7.44 mL	14.88 mL
3.75 mM	0.30 mL	1.49 mL	2.98 mL
7.5 mM	0.15 mL	0.74 mL	1.49 mL
37.5 mM	0.03 mL	0.15 mL	0.30 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 95 publications citing the usage of this product.

Dumont BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y₂ receptor antagonist. Br.J.Pharmacol. 2000 PMID: 10725255
Malmstrom Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y₂ receptor antagonist, in vivo. Br.J.Pharmacol. 2001 PMID: 11487518
Doods BIIE0246: a selective and high affinity neuropeptide Y Y₂ receptor antagonist. Eur.J.Pharmacol. 1999 PMID: 10611450

Product Documents for BIIE 0246

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for BIIE 0246

For research use only

Related Research Areas

Nutrition and Appetite

Obesity

Citations for BIIE 0246

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