BMS 753

Catalog # Availability Size / Price Qty
3505/10
3505/50
BMS 753 | CAS No. 215307-86-1 | Retinoic Acid Receptor Agonists
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Description: RARα-selective agonist

Chemical Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

RARα-selective agonist (Ki = 2 nM).

Technical Data

M.Wt:
351.4
Formula:
C21H21NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
215307-86-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
    Gehin et al.
    Chem.Biol., 1999;6:519
  2. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.
    Taneja et al.
    Proc.Natl.Acad.Sci.USA, 1996;93:6197
  3. Ligand-dependent activation of transcription in vitro by retinoid acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo.
    Dilworth et al.
    Proc.Natl.Acad.Sci.USA, 1999;96:1995

Product Datasheets

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Citation for BMS 753

The citations listed below are publications that use Tocris products. Selected citations for BMS 753 include:

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