BMS 753
Chemical Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid
Purity: ≥99%
Biological Activity
BMS 753 is a RARα-selective agonist (Ki = 2 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
Gehin et al.
Chem.Biol., 1999;6:519 -
Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.
Taneja et al.
Proc.Natl.Acad.Sci.USA, 1996;93:6197 -
Ligand-dependent activation of transcription in vitro by retinoid acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo.
Dilworth et al.
Proc.Natl.Acad.Sci.USA, 1999;96:1995
Product Datasheets
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Citation for BMS 753
The citations listed below are publications that use Tocris products. Selected citations for BMS 753 include:
1 Citation: Showing 1 - 1
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Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
Authors: Raverdeau Et al.
Proc Natl Acad Sci U S A 2012;109:16582
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