Catalog Number: 3505
Chemical Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid
Biological Activity
RARα-selective agonist (Ki = 2 nM).
Technical Data
  • M.Wt:
    351.4
  • Formula:
    C21H21NO4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    215307-86-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
    Gehin et al.
    Chem.Biol., 1999;6:519
  2. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.
    Taneja et al.
    Proc.Natl.Acad.Sci.USA, 1996;93:6197
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS 753 include:

1 Citations: Showing 1 - 1

  1. Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
    Authors: Raverdeau Et al.
    Proc Natl Acad Sci U S A 2012;109:16582

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