Catalog Number: 1442
Chemical Name: [3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid
Biological Activity
Non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC50 = 27-35 nM).
Technical Data
  • M.Wt:
    438.44
  • Formula:
    C26H18N2O5
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    152575-66-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Bristol-Myers Squibb Company
Background References
  1. Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid.
    Meanwell et al.
    , 1993;36:3884
  2. Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon.
    Rudd et al.
    Br.J.Pharmacol., 2000;129:782
  3. [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding.
    Seiler et al.
    Prostaglandins, 1997;53:21

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