Catalog Number: 1188
Biological Activity
Selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Trp-1 = D-Trp, Val-4 = D-Val, Cyclized)

  • Solubility:
    Soluble to 0.40 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Role of endothelin in cardiovascular disease.
    Agapitov and Haynes
    J.Renin Angiotensin Aldosterone Syst., 2002;3:1
  2. Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle.
    Ekelund et al.
    Br.J.Pharmacol., 1994;112:887
  3. Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
    Sakamoto et al.
    J.Biol.Chem., 1993;268:8547
  4. Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on guinea pig respiratory mechanics.
    Makatani et al.
    Eur.J.Pharmacol., 2000;406:139

The citations listed below are publications that use Tocris products. Selected citations for BQ-123 include:

Showing Results 1 - 3 of 3

  1. Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress.
    Authors: Faraco Et al.
    Am J Pathol
  2. Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.
    Authors: Patel Et al.
    J Neurosci
  3. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
    Authors: McQueen Et al.
    Br J Pharmacol
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information