Catalog Number: 1188
Biological Activity
Selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.
Technical Data
  • M.Wt:
    611
  • Formula:
    C31H42N6O7
  • Sequence:
    WDPVL

    (Modifications: Trp-1 = D-Trp, Val-4 = D-Val, Cyclized)

  • Solubility:
    Soluble to 0.40 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    136553-81-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Role of endothelin in cardiovascular disease.
    Agapitov and Haynes
    J.Renin Angiotensin Aldosterone Syst., 2002;3:1
  2. Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle.
    Ekelund et al.
    Br.J.Pharmacol., 1994;112:887
  3. Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
    Sakamoto et al.
    J.Biol.Chem., 1993;268:8547
  4. Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on guinea pig respiratory mechanics.
    Makatani et al.
    Eur.J.Pharmacol., 2000;406:139
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BQ-123 include:

3 Citations: Showing 1 - 3
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  1. Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress.
    Authors: Faraco Et al.
    Am J Pathol 2014;34:852
  2. Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.
    Authors: Patel Et al.
    J Neurosci 2014;184:3040
  3. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
    Authors: McQueen Et al.
    Br J Pharmacol 2007;151:278
Average Rating: 5 (Based on 1 review)

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