BQ-123

  ( 5 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1188
Chemical Name:
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
Selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.
Technical Data
  • M.Wt:
    611
  • Formula:
    C31H42N6O7
  • Sequence:
    WDPVL

    (Modifications: Trp-1 = D-Trp, Val-4 = D-Val, Cyclized)

  • Solubility:
    Soluble to 0.40 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    136553-81-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BQ-123 include:

5 Citations: Showing 1 - 5
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  1. Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress.
    Authors: Faraco Et al.
    Am J Pathol  2014;34:852
  2. Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.
    Authors: Patel Et al.
    J Neurosci  2014;184:3040
  3. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors.
    Authors: Sánchez Et al.
    Br J Pharmacol  2014;171:5682
  4. Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery.
    Authors: Craig and Martin
    Br J Pharmacol  2012;167:527
  5. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
    Authors: McQueen Et al.
    Br J Pharmacol  2007;151:278

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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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