Chemical Name: 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Biological ActivityBupropion hydrochloride is a non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Bupropion is a nicotinic antagonist.
Slemmer et al.
Plasma membrane monoamine transporters: structure regulation and function.
Torres et al.
Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent.
Dwoskin et al.
CNS Drug Rev., 2006;12:178
Citations for Bupropion hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Bupropion hydrochloride include:
4 Citations: Showing 1 - 4
Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells.
Authors: Durham Et al.
Sci Rep 2019;9:3805
Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
Cardiovasc Res 2015;40:766
Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.
Authors: Nunes Et al.
J Neurosci 2013;33:19120
Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
Authors: Li Et al.
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