Catalog Number: 2831
Chemical Name: 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Biological Activity
Non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Bupropion is a nicotinic antagonist.
    Slemmer et al.
    J.Pharmacol.Exp.Ther., 2000;295:321
  2. Plasma membrane monoamine transporters: structure regulation and function.
    Torres et al.
    Nat.Rev.Neurosci., 2003;4:13
  3. Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent.
    Dwoskin et al.
    CNS Drug Rev., 2006;12:178
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