Bupropion hydrochloride

Key Product Details

Product Description

Bupropion hydrochloride is a non-selective inhibitor of dopamine and noradrenalin transporters (K_i values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.

Product Specifications for Bupropion hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Bupropion hydrochloride

The following data is based on the product molecular weight 276.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.10 mL	36.21 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Torres Plasma membrane monoamine transporters: structure regulation and function. Nat.Rev.Neurosci. 2003 PMID: 12511858
• Dwoskin Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent. CNS Drug Rev. 2006 PMID: 17227286
• Slemmer Bupropion is a nicotinic antagonist. J.Pharmacol.Exp.Ther. 2000 PMID: 10991997

Product Documents for Bupropion hydrochloride