Bupropion hydrochloride

Catalog # Availability Size / Price Qty
2831/50
Cat.No. 2831 - Bupropion hydrochloride | C13H18ClNO.HCl | CAS No. 31677-93-7
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Description: Non-selective inhibitor of dopamine and noradrenalin transporters

Chemical Name: 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride

Purity: ≥99%

Product Details
Citations (3)
Supplemental Products
Reviews

Biological Activity

Non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.

Technical Data

M.Wt:
276.2
Formula:
C13H18ClNO.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
31677-93-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Bupropion is a nicotinic antagonist.
    Slemmer et al.
    J.Pharmacol.Exp.Ther., 2000;295:321
  2. Plasma membrane monoamine transporters: structure regulation and function.
    Torres et al.
    Nat.Rev.Neurosci., 2003;4:13
  3. Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent.
    Dwoskin et al.
    CNS Drug Rev., 2006;12:178

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Citations for Bupropion hydrochloride

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