BX 430

Catalog # Availability Size / Price Qty
5545/50
5545/10
Cat.No. 5545 - BX 430 | C15H15Br2N3O | CAS No. 688309-70-8
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Description: Selective P2X4 allosteric antagonist

Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea

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Biological Activity

Selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.

Technical Data

Formula:
C15H15Br2N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
688309-70-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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