Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea
Biological ActivityBX 430 is a selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.
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Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels
Ase et al.
Citation for BX 430
The citations listed below are publications that use Tocris products. Selected citations for BX 430 include:
1 Citation: Showing 1 - 1
HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells.
Authors: Datta Et al.
Front Cell Neurosci 2019;13:329
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