BX 430

Tocris Bioscience | Catalog # 5545

Selective P2X4 allosteric antagonist
Tocris Bioscience

Key Product Details

Description

Selective P2X4 allosteric antagonist
View all P2X Receptor Antagonists »

Product Description

BX 430 is a selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.

Product Specifications for BX 430

Molecular Weight

413.11

Formula

C15H15Br2N3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea

CAS Number

688309-70-8

PubChem ID

2810999

InChI Key

JFNKIJKRXKPQCC-UHFFFAOYSA-N

SMILES

CC(C)C1=CC(Br)=C(NC(NC2=CN=CC=C2)=O)C(Br)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.31 100
Ethanol 41.31 100

Preparing Stock Solutions for BX 430

The following data is based on the product molecular weight 413.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.10 mL 24.21 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for BX 430

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BX 430

For research use only

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