PKR inhibitor (IC50
= 210 nM). Rescues PKR-dependent translation block in vitro
. Decreases Aβ
42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.
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Small molecule inhibitors of the RNA-dependent protein kinase.
Jammi et al.
The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation.
Ingrand et al.
FEBS Lett., 2007;581:4473
Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures.
Couturier et al.
The specific PKR inhibitor C16 prevents apoptosis and IL-1� production in an acute excitotoxic rat model with a neuroinflammatory component.
Tronel et al.