C16

Key Product Details

Product Description

C16 is a PKR inhibitor (IC₅₀ = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.

Product Specifications for C16

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for C16

The following data is based on the product molecular weight 268.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.45 mL	37.27 mL	74.55 mL
2.5 mM	1.49 mL	7.45 mL	14.91 mL
5 mM	0.75 mL	3.73 mL	7.45 mL
25 mM	0.15 mL	0.75 mL	1.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Tronel The specific PKR inhibitor C16 prevents apoptosis and IL-1 beta production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem.Int. 2014 PMID: 24211709
• Ingrand The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. FEBS Lett. 2007 PMID: 17761171
• Couturier Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures. J.Neuroinflammation 2011 PMID: 21699726
• Jammi Small molecule inhibitors of the RNA-dependent protein kinase. Biochem.Biophys.Res.Comm. 2003 PMID: 12890478

Product Documents for C16