Chemical Name: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Biological ActivityC16 is a PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule inhibitors of the RNA-dependent protein kinase.
Jammi et al.
The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation.
Ingrand et al.
FEBS Lett., 2007;581:4473
The specific PKR inhibitor C16 prevents apoptosis and IL-1� production in an acute excitotoxic rat model with a neuroinflammatory component.
Tronel et al.
Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures.
Couturier et al.
Citation for C16
The citations listed below are publications that use Tocris products. Selected citations for C16 include:
1 Citation: Showing 1 - 1
Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells.
Authors: Jiang and Steinle
J Inflamm Res 2019;12:153
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