Inhibitor of cathepsin B (Ki
= 2-5 nM). Displays selectivity over cathepsins H and L (Ki
= 40-200 μ
M). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.
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Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells.
Gillet et al.
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.
Towatari et al.
FEBS Lett., 1991;280:311
Cathepsin B inhibition limits bone metastasis in breast cancer.
Withana et al.
Cancer Res., 2012;72:1199