CA 074

Catalog # Availability Size / Price Qty
CA 074 | CAS No. 134448-10-5 | Synthetic Cathepsin Inhibitors
1 Image
Description: Selective cathepsin B inhibitor

Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

CA 074 is an inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Technical Data

Soluble to 20 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cathepsin B inhibition limits bone metastasis in breast cancer.
    Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, Bidwell B, Edgington L, Wang L, Moin K, Sloane B, Anderson R, Bogyo M, Parker B
    Cancer Res, 0;72(5):1199-209.
  2. Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells.
    Gillet et al.
    J.Biol.Chem., 2009;284:8680
  3. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.
    Towatari et al.
    FEBS Lett., 1991;280:311

Product Datasheets

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Citation for CA 074

The citations listed below are publications that use Tocris products. Selected citations for CA 074 include:

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