CA 074
Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
Purity: ≥98%
Biological Activity
CA 074 is an inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Cathepsin B inhibition limits bone metastasis in breast cancer.
Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, Bidwell B, Edgington L, Wang L, Moin K, Sloane B, Anderson R, Bogyo M, Parker B
Cancer Res, 0;72(5):1199-209. -
Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells.
Gillet et al.
J.Biol.Chem., 2009;284:8680 -
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.
Towatari et al.
FEBS Lett., 1991;280:311
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for CA 074
The citations listed below are publications that use Tocris products. Selected citations for CA 074 include:
1 Citation: Showing 1 - 1
-
C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death.
Authors: Li Et al.
Protein Cell 2018;9:1013
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for CA 074
There are currently no reviews for this product. Be the first to review CA 074 and earn rewards!
Have you used CA 074?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
