Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
Biological ActivityInhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Cathepsin B inhibition limits bone metastasis in breast cancer.
Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, Bidwell B, Edgington L, Wang L, Moin K, Sloane B, Anderson R, Bogyo M, Parker B
Cancer Res, 0;72(5):1199-209.
Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells.
Gillet et al.
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.
Towatari et al.
FEBS Lett., 1991;280:311
Citation for CA 074
The citations listed below are publications that use Tocris products. Selected citations for CA 074 include:
1 Citation: Showing 1 - 1
C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death.
Authors: Li Et al.
Protein Cell 2018;9:1013
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