CA 074

Key Product Details

Product Description

CA 074 is an inhibitor of cathepsin B (K_i = 2-5 nM). Displays selectivity over cathepsins H and L (K_i = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Product Specifications for CA 074

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CA 074

The following data is based on the product molecular weight 383.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.04 mL	65.20 mL	130.40 mL
1 mM	2.61 mL	13.04 mL	26.08 mL
2 mM	1.30 mL	6.52 mL	13.04 mL
10 mM	0.26 mL	1.30 mL	2.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Towatari Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 1991 PMID: 2013329
• Withana Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 2012 PMID: 22266111
• Gillet Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 2009 PMID: 19176528

Product Documents for CA 074