Catalog Number: 4863
Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
Biological Activity
Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.
Technical Data
  • M.Wt:
    383.44
  • Formula:
    C18H29N3O6
  • Solubility:
    Soluble to 20 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    134448-10-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells.
    Gillet et al.
    J.Biol.Chem., 2009;284:8680
  2. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.
    Towatari et al.
    FEBS Lett., 1991;280:311
  3. Cathepsin B inhibition limits bone metastasis in breast cancer.
    Withana et al.
    Cancer Res., 2012;72:1199

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