Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
Biological ActivityInhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cathepsin B inhibition limits bone metastasis in breast cancer.
Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, Bidwell B, Edgington L, Wang L, Moin K, Sloane B, Anderson R, Bogyo M, Parker B
Cancer Res, 0;72(5):1199-209.
Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells.
Gillet et al.
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.
Towatari et al.
FEBS Lett., 1991;280:311
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for CA 074
There are currently no reviews for this product. Be the first to review CA 074 and earn rewards!
Have you used CA 074?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image