Catalog Number: 4877
Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Biological Activity
Calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).
Technical Data
  • M.Wt:
    347.43
  • Formula:
    C18H21NO4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    407587-33-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
    Namkung et al.
    J.Biol.Chem., 2011;286:2365
  2. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel.
    De La Fuente et al.
    Mol.Pharmacol., 2008;73:758

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