Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Biological ActivityCalcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
Namkung et al.
Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel.
De La Fuente et al.
Citation for CaCCinh-A01
The citations listed below are publications that use Tocris products. Selected citations for CaCCinh-A01 include:
1 Citation: Showing 1 - 1
Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.
Authors: Amjad Et al.
J Gen Physiol 2015;145:285
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