Calyculin A

Tocris Bioscience | Catalog # 1336

Protein phosphatase 1 and 2A inhibitor
Tocris Bioscience

Key Product Details

Description

Protein phosphatase 1 and 2A inhibitor
View all Protein Ser/Thr Phosphatase Inhibitors »

Product Description

Calyculin A is a potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Note: This product is typically prepared in DMSO.

Product Specifications for Calyculin A

Molecular Weight

1009.18

Formula

C50H81N4O15P

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide

CAS Number

101932-71-2

PubChem ID

3894

InChI Key

ULTTYPMRMMDONC-UHFFFAOYSA-N

SMILES

O[C@H]1[C@H](C)[C@H](C/C=C/C3=COC([C@@H](C)CCNC([C@H]([C@H]([C@@H](N(C)C)COC)O)O)=O)=N3)O[C@]2([C@](C)(C)[C@@H](OP(O)(O)=O)[C@]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=C\C#N)([H])O2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 53 publications citing the usage of this product.

Product Documents for Calyculin A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Calyculin A

For research use only

Related Research Areas

Epigenetics
Phosphatases and Regulators

Customer Reviews for Calyculin A (1)

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  • Product performed ideally over years and would buy again.
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    calyculin A for PP1/PP2A (Cal A, 100 nM)
    Calyculin A 1336

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