Catalog Number: 1336
Chemical Name: N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl
Biological Activity
Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.
Technical Data
  • M.Wt:
    1009.18
  • Formula:
    C50H81N4O15P
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    101932-71-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin.
    Favre et al.
    J.Biol.Chem., 1997;272:13856
  2. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
    Ishihara et al.
    Biochem.Biophys.Res.Commun., 1989;159:871
  3. Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies.
    McCluskey et al.
    J.Med.Chem., 2002;45:1151
  4. The binding mode of calyculin A to protein phosphatase-1.
    Lindval et al.
    J.Biol.Chem., 1997;272:23312
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Calyculin A include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.
    Authors: Chazeau Et al.
    J Neurochem 2015;26:859
  2. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.
    Authors: Isensee Et al.
    J Cell Sci 2014;127:216

Have you used Calyculin A?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information