Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50
= 0.3 - 0.7 nM) and protein phosphatase 2A (IC50
= 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.
Soluble to 50 mM in DMSO
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin.
Favre et al.
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
Ishihara et al.
Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies.
McCluskey et al.
The binding mode of calyculin A to protein phosphatase-1.
Lindval et al.
The citations listed below are publications that use Tocris products. Selected citations for Calyculin A include:
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