Catalog Number: 1333
Chemical Name: (S)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Biological Activity
Cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.

R-enantiomer also available.

Technical Data
  • M.Wt:
    446.46
  • Formula:
    C10H12N5O5PS.C6H15N
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    93602-66-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.
    Dostmann et al.
    J.Biol.Chem., 1990;265:10484
  2. A family of cAMP-binding proteins that directly activate Rap1.
    Kawasaki et al.
    Science, 1998;282:2275
  3. Ethanol inhibition of NMDA-induced responses and actute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases.
    Lin et al.
    Neuropharmacology, 2006;51:747
  4. A kinetic study of interactions of (Rp)- and (Sp)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase.
    O'Brian et al.
    Biochemistry, 1982;21:4371
Citations:

The citations listed below are publications that use Tocris products. Selected citations for cAMPS-Sp, triethylammonium salt include:

1 Citations: Showing 1 - 1

  1. Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats.
    Authors: Keng Et al.
    J Biomed Sci 2012;19:11

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