Catalog Number: 4098
Alternate Names: CBZ
Chemical Name: 5H-Dibenz[b,f]azepine-5-carboxamide
Biological Activity
Inhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin.
    Granger et al.
    Mol.Pharmacol., 1995;47:1189
  2. Lamotrigine and carbamazepine affect differently the release of D-[3H] aspartate from mouse cerebral cortex slices: involvement of NO.
    Afanas'ev et al.
    Neurochem.Res., 1999;24:1153
  3. Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.
    Lipkind and Fozzard
    Mol.Pharmacol., 2010;78:631
  4. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
    Sarkar et al.
    Cell Death Differ., 2009;16:46
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