Chemical Name: 5H-Dibenz[b,f]azepine-5-carboxamide
Biological ActivityCarbamazepine is an inhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also delays disease onset and prolongs survival in a mouse amyotrophic lateral sclerosis (ALS) model, as well as reducing motor neuron loss and altered muscle morphology.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.
Lipkind and Fozzard
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
Sarkar et al.
Cell Death Differ., 2009;16:46
Repurposing carbamaz. for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model.
Zhang et al.
CNS Neurosci.Ther., 2018;24:1163
Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamaz. and phen.
Granger et al.
Lamotrigine and carbamaz. affect differently the release of D-[3H] aspartate from mouse cerebral cortex slices: involvement of NO.
Afanas'ev et al.
Citations for Carbamazepine
The citations listed below are publications that use Tocris products. Selected citations for Carbamazepine include:
4 Citations: Showing 1 - 4
Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate.
Authors: Hui Et al.
Mol Cell 2022;82:2401-2414.e9
Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro.
Authors: Eero Et al.
Front Pharmacol 2022;12:755600
Cerebellar spreading depolarization mediates paroxysmal movement disorder.
Authors: Jing Et al.
Cell Rep 2021;36:109743
Mechanisms for Selective Single-Cell Reactivation during Offline Sharp-Wave Ripples and Their Distortion by Fast Ripples.
Authors: Gábor Et al.
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