Inhibitor of neuronal voltage-gated Na
channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl
currents in HEK 293 cells expressing the GABA
2 subtype combination. Can induce autophagy by inhibiting inositol synthesis.
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Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin.
Granger et al.
Lamotrigine and carbamazepine affect differently the release of D-[ 3H] aspartate from mouse cerebral cortex slices: involvement of NO.
Afanas'ev et al.
Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.
Lipkind and Fozzard
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
Sarkar et al.
Cell Death Differ., 2009;16:46
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
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