Carbamazepine

Catalog # Availability Size / Price Qty
4098/50
Carbamazepine | CAS No. 298-46-4 | Voltage-gated Sodium Channel Inhibitors
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Description: Inhibitor of neuronal NaV channels; anticonvulsant
Alternative Names: CBZ

Chemical Name: 5H-Dibenz[b,f]azepine-5-carboxamide

Purity: ≥99%

Product Details
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Biological Activity

Inhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also delays disease onset and prolongs survival in a mouse amyotrophic lateral sclerosis (ALS) model, as well as reducing motor neuron loss and altered muscle morphology.

Technical Data

M.Wt:
236.27
Formula:
C15H12N2O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
298-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Carbamazepine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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